Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Sex does not affect death risk in young AMI patients

15 Feb 2020

Sex does not appear to affect acute myocardial infarction (AMI) survival outcomes in younger patients, a recent US study has found.

Researchers conducted a retrospective analysis of the National Inpatient Sample including 156,018 AMI patients aged 18 to <45 years. Of these, 111,894 were men and 44,124 were women. Outcomes included in-hospital all-cause mortality, complications and revascularization studies, compared between sex groups.

AMI comorbidities occurred more frequently in women, including anaemia (15 percent vs 5.3 percent; p<0.001), chronic lung diseases (15.6 percent vs 7.5 percent; p<0.001) and obesity (31 percent vs 21.6 percent; p<0.001). The same was true for peripheral vascular disease, renal failure, and fluid and electrolyte disorders.

On the other hand, dyslipidaemia (60 percent vs 50.7 percent; p<0.001), smoking (52.7 percent vs 49.7 percent; p<0.001) and alcohol abuse (6.2 percent vs 2.2 percent; p<0.001) were significantly more common in men.

Despite these differences, survival outcomes were comparable between sexes. In-hospital all-cause mortality, for instance, occurred in 2 percent of women and 1.5 percent in men, yielding a nonsignificant difference in likelihood (odds ratio [OR], 1.04, 95 percent confidence interval [CI], 0.84–1.29; p=0.68). This held true even after analyses in different subgroups.

Women, however, were significantly less likely to receive percutaneous coronary intervention with stent placement (OR, 0.66, 95 percent CI, 0.62–0.70; p<0.001) and coronary artery bypass grafting (OR, 0.73, 95 percent CI, 0.64–0.83; p<0.001) than men.

In terms of complications, women were at a lower risk of cardiogenic shock, ventricular arrhythmia and acute kidney injury, but at a higher risk of major bleeding requiring transfusion, mitral regurgitation and respiratory failure, relative to men.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.