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Stephen Padilla, 2 days ago
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Jairia Dela Cruz, 2 days ago
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Severity of sacroiliitis, ESR tied to low trabecular bone score in men with ankylosing spondylitis

07 Mar 2018

The use of trabecular bone score (TBS) may be helpful in evaluating osteoporosis in ankylosing spondylitis (AS), as it is associated with the erythrocyte sedimentation rate (ESR) and severity of sacroiliitis in young male patients with AS, suggests a recent study.

The TBS had a mean of 1.38. It was positively associated with bone mineral density (BMD) at the lumbar spine, femoral neck and total hip, and negatively associated with the Stoke Ankylosing Spondylitis Spine Score (SASSS).

Patients with spinal structural damage showed a significant reduction in TBS values (p=0.001). In univariate analysis, TBS correlated with disease duration, ESR, sacroiliitis grade and SASSS, while multivariate analysis identified ESR (p=0.006) and sacroiliitis grade (p<0.001) as independently correlated with TBS.

Morphometric vertebral fractures were present in 10 patients. Those with vertebral fractures had lower mean TBS than age-matched patients without fractures (p=0.028). Lower TBS was found to be a predictor of vertebral fractures (area under curve, 0.733; cutoff, 1.311).

The authors enrolled 100 patients (aged <50 years; 100 percent male) who fulfilled the modified New York criteria for the classification of AS to examine factors related to a low TBS and the association between TBS and vertebral fractures in AS patients.

Using dual-energy X-ray absorptiometry, the TBS and BMD were calculated. In addition, the authors assessed clinical variables, inflammatory markers and the presence of vertebral fractures. They used the modified New York criteria and the SASSS to measure sacroiliitis grade and spinal structural damage.

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Most Read Articles
Stephen Padilla, 2 days ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 4 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
15 Jun 2018
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Jairia Dela Cruz, 2 days ago
A treatment regimen combining daratumumab plus bortezomib, melphalan and prednisone markedly extends progression-free survival in patients with multiple myeloma, inducing deep responses and demonstrating acceptable tolerability regardless of baseline renal function, according to the results of the phase III ALCYONE study.