Most Read Articles
30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia. 
Stephen Padilla, 20 Nov 2017
Diclofenac reduces the use of antibiotics in women with uncomplicated lower urinary tract infection (UTI) but remains less effective than norfloxacin for symptom relief of UTI, according to a recent study. In addition, diclofenac appears to be associated with an elevated risk of pyelonephritis.

Severe coma, renal failure predict mortality in elderly with dengue

07 Oct 2017
Dengue cases in Sri Lanka, India have been recorded twice as many compared to last year.

Survival rate in geriatric patients with dengue fever is high, given the absence of any of the following predictors: severe coma, severe hepatitis, renal failure and being bedridden, a new retrospective case-control study has shown.

In contrast, those with at least two predictors have an almost 60 percent mortality rate.

Medical records of 627 elderly patients (mean age 74.09±6.28 years) who were admitted into a tertiary medical hospital during the 2015 dengue fever outbreak in Taiwan were accessed. Of these, 27 patients had died, resulting in a mortality rate of 4.3 percent.

In terms of comorbidity, patients who died had significantly higher percentages of pressure ulcer (p=0.015), anaemia (p=0.04), respiratory failure (p<0.001), diabetes mellitus (p=0.038) and coronary artery disease (p=0.04), among other conditions, than those without mortality.

In multivariate logistic regression analysis, severe coma (adjusted odds ratio [OR], 11.36; 95 percent CI, 1.89 to 68.19; p=0.08), being bedridden (adjusted OR, 10.46; 1.58 to 69.16; p=0.015), severe hepatitis (adjusted OR, 96.08; 14.11 to 654.39; p<0.001) and renal failure (adjusted OR, 6.03; 1.50 to 24.246; p=0.011) were the four significant predictors of mortality.

When combined, all four predictors yielded a sensitivity of 70.37 percent for patients with at least one predictor. The specificity, positive predictive value (PPV) and negative predictive value (NPV) were 88.17, 21.11 and 98.51 percent, respectively.

In comparison, sensitivity for those with at least two predictors was 33.33 percent. The corresponding specificity, PPV and NPV were 99.44, 57.14 and 98.51 percent.

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Most Read Articles
30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia. 
Stephen Padilla, 20 Nov 2017
Diclofenac reduces the use of antibiotics in women with uncomplicated lower urinary tract infection (UTI) but remains less effective than norfloxacin for symptom relief of UTI, according to a recent study. In addition, diclofenac appears to be associated with an elevated risk of pyelonephritis.