Most Read Articles
01 Aug 2014

Extracted from the speech by UNAIDS Executive Director Michel Sidibé at the opening session of the 20th International AIDS Conference (AIDS 2014) held in Melbourne, Australia.

24 Dec 2015
Imipenem-cilastatin exhibited better efficacy than piperacillin-tazobactam as empiric antibiotic for febrile neutropaenia in haematopoietic stem cell transplantation (HSCT) recipients, based on a study.

Severe coma, renal failure predict mortality in elderly with dengue

07 Oct 2017
Dengue cases in Sri Lanka, India have been recorded twice as many compared to last year.

Survival rate in geriatric patients with dengue fever is high, given the absence of any of the following predictors: severe coma, severe hepatitis, renal failure and being bedridden, a new retrospective case-control study has shown.

In contrast, those with at least two predictors have an almost 60 percent mortality rate.

Medical records of 627 elderly patients (mean age 74.09±6.28 years) who were admitted into a tertiary medical hospital during the 2015 dengue fever outbreak in Taiwan were accessed. Of these, 27 patients had died, resulting in a mortality rate of 4.3 percent.

In terms of comorbidity, patients who died had significantly higher percentages of pressure ulcer (p=0.015), anaemia (p=0.04), respiratory failure (p<0.001), diabetes mellitus (p=0.038) and coronary artery disease (p=0.04), among other conditions, than those without mortality.

In multivariate logistic regression analysis, severe coma (adjusted odds ratio [OR], 11.36; 95 percent CI, 1.89 to 68.19; p=0.08), being bedridden (adjusted OR, 10.46; 1.58 to 69.16; p=0.015), severe hepatitis (adjusted OR, 96.08; 14.11 to 654.39; p<0.001) and renal failure (adjusted OR, 6.03; 1.50 to 24.246; p=0.011) were the four significant predictors of mortality.

When combined, all four predictors yielded a sensitivity of 70.37 percent for patients with at least one predictor. The specificity, positive predictive value (PPV) and negative predictive value (NPV) were 88.17, 21.11 and 98.51 percent, respectively.

In comparison, sensitivity for those with at least two predictors was 33.33 percent. The corresponding specificity, PPV and NPV were 99.44, 57.14 and 98.51 percent.

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Most Read Articles
01 Aug 2014

Extracted from the speech by UNAIDS Executive Director Michel Sidibé at the opening session of the 20th International AIDS Conference (AIDS 2014) held in Melbourne, Australia.

24 Dec 2015
Imipenem-cilastatin exhibited better efficacy than piperacillin-tazobactam as empiric antibiotic for febrile neutropaenia in haematopoietic stem cell transplantation (HSCT) recipients, based on a study.