Most Read Articles
13 Mar 2017
The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
Clare Cuckson, 01 Jun 2012
During pregnancy, there is generalized relaxation of smooth muscle resulting in relaxa¬tion of the oesophageal sphincter, reduced gastric peristalsis, and delayed gastric emp¬tying. Small and large bowel transit times are increased. There is increased blood flow to the liver and increased production of fibrinogen, transferrin and many other binding proteins. Reference ranges for many liver function tests are altered. Gestation-specific alkaline phosphatase is increased, mainly from increased placental production, and aminotransferases and γ-glutamyltransferase are reduced.

 

Sessile serrated adenomas may have low risk of malignant progression in young patients

12 Apr 2018

Sessile serrated adenomas (SSAs) appear to have a prolonged dwell time and are unlikely to develop into cancer, especially in young patients, a study suggests.

Researchers examined two separate cohorts consisting of a consecutive series of patients who underwent outpatient colonoscopy (polyp cohort; mean age 58 years; 50.6 percent female) and a consecutive series of patients who contributed resection specimens for colorectal carcinoma (CRC; cancer cohort; mean age 69 years; 46.8 percent female).

SSA prevalence by age was compared against the ages of patients with BRAF-mutated CRC. Results showed that the prevalence of SSAs in the polyp cohort was 20.1 percent, and the rate was similar across age groups. On the other hand, BRAF-mutated CRCs in the cancer cohort were very rare (3.8 percent) in patients aged <50 years and uncommon (9.3 percent) in those aged <60 years, but increased to 39.8 percent in older patients (age >80 years).

The present data demonstrate a high prevalence of SSAs in young patients, but a distinct lack of BRAF-mutated carcinomas in patients aged <60 years, suggesting that the risk of malignant progression for sporadic SSAs in young patients is low, researchers said.

However, researchers warned that young patients with serrated polyposis syndrome are of course at a greater risk of developing CRC and require very close surveillance. Patients with multiple SSAs but who do not meet the criteria for serrated polyposis syndrome should also be followed closely as polyp counts are usually considered to be cumulative over time.

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Most Read Articles
13 Mar 2017
The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
Clare Cuckson, 01 Jun 2012
During pregnancy, there is generalized relaxation of smooth muscle resulting in relaxa¬tion of the oesophageal sphincter, reduced gastric peristalsis, and delayed gastric emp¬tying. Small and large bowel transit times are increased. There is increased blood flow to the liver and increased production of fibrinogen, transferrin and many other binding proteins. Reference ranges for many liver function tests are altered. Gestation-specific alkaline phosphatase is increased, mainly from increased placental production, and aminotransferases and γ-glutamyltransferase are reduced.