Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
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Vitamin E supplementation does not appear to contribute to blood pressure (BP) improvement, with results of a recent systematic review and meta-analysis showing decreases only in systolic (S)BP but no favourable effect on diastolic (D)BP and mean arterial pressure (MAP).

Sessile serrated adenomas may have low risk of malignant progression in young patients

12 Apr 2018

Sessile serrated adenomas (SSAs) appear to have a prolonged dwell time and are unlikely to develop into cancer, especially in young patients, a study suggests.

Researchers examined two separate cohorts consisting of a consecutive series of patients who underwent outpatient colonoscopy (polyp cohort; mean age 58 years; 50.6 percent female) and a consecutive series of patients who contributed resection specimens for colorectal carcinoma (CRC; cancer cohort; mean age 69 years; 46.8 percent female).

SSA prevalence by age was compared against the ages of patients with BRAF-mutated CRC. Results showed that the prevalence of SSAs in the polyp cohort was 20.1 percent, and the rate was similar across age groups. On the other hand, BRAF-mutated CRCs in the cancer cohort were very rare (3.8 percent) in patients aged <50 years and uncommon (9.3 percent) in those aged <60 years, but increased to 39.8 percent in older patients (age >80 years).

The present data demonstrate a high prevalence of SSAs in young patients, but a distinct lack of BRAF-mutated carcinomas in patients aged <60 years, suggesting that the risk of malignant progression for sporadic SSAs in young patients is low, researchers said.

However, researchers warned that young patients with serrated polyposis syndrome are of course at a greater risk of developing CRC and require very close surveillance. Patients with multiple SSAs but who do not meet the criteria for serrated polyposis syndrome should also be followed closely as polyp counts are usually considered to be cumulative over time.

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Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
13 Mar 2019
Vitamin E supplementation does not appear to contribute to blood pressure (BP) improvement, with results of a recent systematic review and meta-analysis showing decreases only in systolic (S)BP but no favourable effect on diastolic (D)BP and mean arterial pressure (MAP).