Most Read Articles
Pearl Toh, 19 Jan 2018
Blood pressure (BP) control can be best achieved with a multilevel, multicomponent approach involving team-based care with physician- and non-physician-led interventions, as well as patient-level strategies, according to findings of a meta-analysis.
Pearl Toh, 09 Oct 2018
Not only are probiotics healthy for the gut, they may also be good for the waistline. A recent study shows that supplementation with the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) improves anthropometric adiposity measures such as waist circumference, body mass index (BMI), and visceral fat area in abdominally obese individuals, particularly in women.

Serum uric acid found to have U-shaped association with stroke mortality

18 Jun 2020

Both elevated and lower serum uric acid (UA) levels bear an excess risk of death from stroke, a study has found. Additionally, hyperuricaemia is associated with coronary heart disease (CHD) mortality.

Researchers followed for 19 years a total of 2,633 community-dwelling Japanese adults aged ≥40 years without a history of cardiovascular disease (CVD) at baseline. A total of 235 individuals died from CVD, including 84 from stroke and 53 from CHD.

Cox proportional hazards models revealed a U-shaped association between serum UA and CVD mortality, with the lowest (Q1, 35–268 µmol/l) and highest (Q5, 412–690 µmol/l) quintiles associated with a risk increase compared with the middle quintile (Q3, 323–357 µmol/; Q1: hazard ratio [HR], 1.50, 95 percent confidence interval [CI], 0.94–2.39; Q5: HR, 1.89, 95 percent CI, 1.23–2.91).

A similar association was noted between serum UA and mortality from stroke. The HRs associated with Q1 and Q3 values were (Q1 vs Q3: HR, 3.26, 95 percent CI, 1.29–8.25; Q5 vs Q3: HR, 3.77, 95 percent CI, 1.54–9.24).

In contrast, the age- and sex-adjusted mortality rate of CHD tended to increase with increasing UA levels, although the p-value for the trend failed to reach significance (Q5 vs Q3: HR, 2.53, 95 percent CI, 1.03–6.18).

More studies are needed to clarify the role of UA in the development of CVD and to establish a strategy for the risk-stratification and prevention of CVD in clinical practice.

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Most Read Articles
Pearl Toh, 19 Jan 2018
Blood pressure (BP) control can be best achieved with a multilevel, multicomponent approach involving team-based care with physician- and non-physician-led interventions, as well as patient-level strategies, according to findings of a meta-analysis.
Pearl Toh, 09 Oct 2018
Not only are probiotics healthy for the gut, they may also be good for the waistline. A recent study shows that supplementation with the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) improves anthropometric adiposity measures such as waist circumference, body mass index (BMI), and visceral fat area in abdominally obese individuals, particularly in women.