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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
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Serum urate-related genetic variants contribute to gout risk in people on diuretics

29 Nov 2020

Serum urate (SU)-associated genetic variants have a robust impact on gout risk among individuals taking diuretics, with an effect comparable to those not taking the said agent, according to a recent study.

Using the UK Biobank Resource, the authors identified 359,876 participants and tested 10 SU-related single-nucleotide polymorphisms (SNP) for their association with gout according to diuretic use. Then, they examined gene-diuretic interactions for gout association using a genetic risk score (GRS) and individual SNP by logistic regression adjusting for relevant confounders.

Use of a loop diuretic showed a positive correlation with prevalent gout (odds ratio [OR], 2.34, 95 percent confidence interval [CI], 2.08–2.63) after adjustment, whereas thiazide diuretics exhibited an inverse association with prevalent gout (OR, 0.60, 95 percent CI, 0.55–0.66).

A higher GRS (≥ mean) positively correlated with gout in people not taking diuretics (OR, 2.63, 95 percent CI, 2.49–2.79), in those taking loop diuretics (OR, 2.04, 95 percent CI, 1.65–2.53), in those on thiazide diuretics (OR, 2.70, 2.26–3.23), and in those receiving thiazide-like diuretics (OR, 2.11, 95 percent CI, 1.37–3.25) relative to a lower GRS (< mean).

“These findings suggest that the contribution of genetic variants is not restricted to people with ‘primary’ gout, and that genetic variants can play an important role in gout susceptibility in the presence of other risk factors,” the authors said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.