Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Serum HMGB1 predicts onset, severity of AE-IPF

20 Mar 2020
Smoking is one cause of idiopathic pulmonary fibrosis, apart from hereditary factors and inhalation of certain types of dust.

Increased levels of serum high-mobility group box 1 (HMGB1) is associated with earlier onset of acute exacerbation (AE) in stable idiopathic pulmonary fibrosis (IPF) patients and shorter survival in those with AE-IPF, a recent study has shown. This signifies that HMGB1 predicts the acute deterioration of IPF.

HMGB1 is a known mediator of acute lung injury owing to the acceleration of proinflammatory signaling, according to the investigators.

This study sought to determine the predictive value of circulatory HMGB1 for disease progression and prognosis of IPF in the stable phase and AE phase. Seventy-six patients with stable IPF, 17 with AE-IPF, 37 with chronic obstructive pulmonary disease (COPD) and 74 healthy controls were included in this analysis. Comparisons were made on serum HMGB1 levels among the four groups.

In stable IPF patients, the investigators examined the association of HMGB1 levels with the onset of AE and prognosis. Furthermore, the prognostic value of HMGB1 was determined in AE-IPF.

Patients with stable IPF had significantly higher serum HMGB1 levels than those in healthy controls (6.26±5.27 vs 3.42±2.69 ng/mL). However, those with AE-IPF (19.20±16.76 ng/mL) showed even higher levels than both stable IPF patients and controls.

No significant difference was observed in serum HMGB1 levels between stable IPF patients and those with COPD. In addition, higher HMGB1 levels predicted earlier onset of AE in stable IPF patients (p=0.030) as well as shorter survival in patients with AE-IPF (p=0.001).

“Previous studies showed that HMGB1 is increased in the lung and circulation of patients with AE‐IPF,” the investigators said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.