Most Read Articles
01 Nov 2014
Current management of liver abscess is by intravenous antibiotics and percutaneous treatment. The efficacy of this management was assessed in this study.
05 Aug 2014
Clinical and laboratory data of acute kidney injury in patients with liver abscess were analyzed in this review.
08 Oct 2014
Anal fissure is an ulceration of the anoderm in the anal canal. Treatments usually do not target these causative factors. Recently, this review has been published giving an update on the management of anal fissure.
15 Feb 2012
This intervention review assessed the efficacy and morbidity of various anal fissure medical therapies in place for surgery.

Serum chemerin tied to quality of life in colorectal cancer survivors

17 May 2017

Serum chemerin levels have a weak but significant association with quality of life (QoL) of survivors of colorectal cancer (CRC), a new study shows.

The study included 110 survivors (mean age 56.29±9.27 years; 50 percent male) of stage 2 or 3 CRC. All participants had completed standard treatment regimens within 6 weeks and 1 year before study enrolment; all were above the age of 20 years. Those with histories of cancer, chronic diseases and abnormal liver and kidney function were excluded.

Participant QoL was assessed using the Functional Assessment of Cancer Therapy (FACT)-General (FACT-G), total FACT-cancer-related (FACT-C) and total FACT-fatigue (FACT-F) questionnaires. Serum chemerin, white blood cell count, total cholesterol, triglyceride and fasting insulin levels, among other markers, were measured from blood samples.

The mean serum chemerin level of the participants was 104.69±14.31 ng/mL.Stage 2 and 3 CRC was reported in 49.1 (n=54) and 50.9 (n=56) percent of the participants, respectively. Furthermore, 91.8 (n=101) and 8.2 (n=9) percent were treated with surgery pluschemotherapy and surgery plus chemoradiotherapy, respectively.

Mean FACT-G, FACT-C and FACT-F scores were 80.57±13.68, 100.89±16.53 and 122.40±19.40, respectively. FACT-G scores were significantly negatively correlated with age (p=0.04), fat percentage (p=0.04), triglyceride levels (p=0.02), high-sensitivity C-reactive protein (hsCRP; p=0.02) and serum chemerin levels (p<0.01).

Similarly, FACT-C scores were negatively associated with triglyceride (p=0.02), hsCRP (p=0.02), fat percentage (p=0.04), age (p=0.04) and serum chemerin levels (p<0.01). On the other hand, only triglyceride (p=0.02) and serum chemerin (p<0.01) were significantly negatively associated with FACT-F scores.

Finally, even after adjusting for potential confounders, FACT-G (β, -0.12; p=0.02), FACT-C (β, -0.14; p=0.02) and FACT-F (β, -0.20; p<0.01) were still significantly independently associated with serum chemerin.

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Most Read Articles
01 Nov 2014
Current management of liver abscess is by intravenous antibiotics and percutaneous treatment. The efficacy of this management was assessed in this study.
05 Aug 2014
Clinical and laboratory data of acute kidney injury in patients with liver abscess were analyzed in this review.
08 Oct 2014
Anal fissure is an ulceration of the anoderm in the anal canal. Treatments usually do not target these causative factors. Recently, this review has been published giving an update on the management of anal fissure.
15 Feb 2012
This intervention review assessed the efficacy and morbidity of various anal fissure medical therapies in place for surgery.