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Serum AST, ALT, GGT, ALP predict incident type 2 diabetes

16 Jul 2017
The current blood glucose monitor requires a disposable test strip and a small drop of blood.

Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.

Multiple cox regression models showed that NAFLD (hazard ratio [HR], 2.08; 95 percent CI, 1.93 to 2.23; p<0.001) and elevated levels of ALT (HR, 1.27; 1.16 to 1.38; p<0.001), AST (HR, 1.23; 1.13 to 1.34; p<0.001), GGT (HR, 1.58; 1.46 to 1.72; p<0.001) and ALP (HR, 1.37; 1.17 to 1.60; p<0.001) were independent risk factors for diabetes in males after adjusting for confounders.

Similarly, NAFLD (HR, 2.65; 2.43 to 2.88; p<0.001) and elevated levels of ALT (HR, 1.56; 1.37 to 1.77; p<0.001), AST (HR, 1.18; 1.04 to 1.34; p<0.01), GGT (HR, 1.48; 1.32 to 1.65; p<0.001) and ALP (HR, 1.44; 1.25 to 1.66; p<0.001) were independent predictors of diabetes in females.

Defined as being in the top 25 percent of abnormal values, extremely high levels of ALT (HR, 1.44; 1.24 to 1.67; p<0.001), AST (HR, 1.36; 1.17 to 1.58; p<0.001), GGT (HR 1.58; 1.37 to 1.84; p<0.001) and ALP (HR, 1.54; 1.16 to 2.03; p<0.01) were associated with higher risks of incident diabetes in males.

On the other hand, only extremely high AST levels (HR, 1.58; 1.27 to 1.96; p<0.001) resulted in higher risks of incident diabetes in females.

The study involved 132,377 healthy, nondiabetic individuals between the ages of 35 and 79. Of these, 6,555 (3,734 males; 2,821 females) developed incident diabetes over the course of the study. The incidence rates in males in females were 9.97 and 7.11 per 1,000 person-years, respectively.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
6 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.