Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
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Serum amyloid A a valuable biomarker in acute anterior uveitis

02 Sep 2020

Patients with acute anterior uveitis (AAU) see elevated levels of serum amyloid A (SAA), which may help in monitoring inflammatory processes and assess the efficacy of therapies, a recent study has found.

Researchers enrolled 108 AAU patients (median age, 41.5 years; 59 males), from whom blood samples were collected and subjected to immunochromatography analysis, for the measurement of biomarkers. A parallel group of 18 healthy controls (mean age, 29.5±8.3 years; 11 males) was included.

Median SAA concentrations were significantly lower in healthy controls than in AAU patients (0 vs 3.83 mg/L; p<0.0001). Stratifying AAU patients according to the presence of human leukocyte antigen-B27 (HLA-B27) showed that patients positive for the marker had significantly higher median SAA levels (4.19 vs 2.83 mg/L; p=0.014).

A similar discrepancy was reported when categorizing patients according to ankylosing spondylitis (AS). SAA was significantly higher in those with vs without AS (4.31 vs 3.51 mg/L; p=0.024). SAA was also elevated in patients with active vs inactive AAU (5.42 vs 2.81 mg/L; p<0.0001).

SAA levels also showed strong predictive value for the active inflammation of AAU. At a cutoff value of 3.22 mg/L, the area under the receiver operating curve was 0.727, with sensitivity and specificity values of 77.2 percent and 60.8 percent, respectively.

Twelve patients were followed to assess the effect of treatment. SAA level dropped significantly after intervention (10.9 to 3.61 mg/L; p=0.0002), coinciding with the improvement of AAU inflammation.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.