Most Read Articles
5 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
4 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
2 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.

Serum aluminium tied to uraemic pruritus during haemodialysis

04 Dec 2018

Concentrations of aluminium in the serum may be correlated with uraemic pruritus (UP) development in patients receiving maintenance haemodialysis (HD), reports a recent study.

Researchers performed a cross-sectional analysis of 866 patients (mean age 56.18±13.59 years; 440 males) undergoing maintenance HD for a mean of 6.96±5.35 years. In this group, the median serum aluminium was 0.9 µg/dL and 21.8 percent (n=189) had UP. Serum aluminium in those with UP were significantly higher than in those without (p<0.001).

Using a threshold value of 2 µg/dL, researchers classified participants into those with high (n=119) or low (n=747) serum aluminium. The proportion of patients with UP was significantly higher in the former group (34.5 percent vs 19.8 percent; p=0.001).

Multivariate logistic regression analysis further showed that the log of serum aluminium concentration was a significant risk factor for UP development (odds ratio [OR], 5.64; 95 percent CI, 3.13–10.17; p<0.001). Moreover, having serum aluminium 2 µg/dL was also associated with a higher UP risk (OR, 2.38; 1.49–3.79; p<0.001).

Other potential risk factors included body mass index, serum levels of cholesterol, albumin and low-density lipoprotein, duration of haemodialysis, normalized protein catabolism rate, and comorbidities such as diabetes mellitus and hepatitis C virus infection. However, the significance of these were attenuated upon multivariable adjustments.

Limitations of the present study included its cross-sectional and single-centre design, as well as the lack of information regarding the aluminium content of the participants’ diets, said researchers. Further research is thus needed to determine the role of aluminium on UP development.

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Most Read Articles
5 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
4 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
2 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.