Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.

Serositis tied to autoimmune thyroid disease in SLE patients

05 Nov 2018

Serositis appears to be an important risk factor for autoimmune thyroid disease (AITD) in people with systemic lupus erythematosus (SLE), reports a new study.

Thirty-eight patients with SLE and AITD (SLE-AITD; mean age 35.36±11.65; 89.5 percent female) were included in the study along with 190 age- and gender-matched SLE-only controls (mean age 35.36±11.54 years; 89.5 percent female). Multivariate logistic regression models were constructed to determine important factors associated with the prevalence of AITD among SLE patients.

Hyperthyroidism was reported in nine of the SLE-AITD participants, all of whom had signs of Graves’ disease. The remaining 29 SLE-AITD patients had hypothyroidism, most of whom (93.10 percent) received thyroxin replacement therapy. All the SLE-AITD participants tested positive for antithyroid antibodies.

Serositis (odds ratio [OR], 3.27; 95 percent CI, 1.59–6.75; p=0.00), the presence of anti-dsDNA antibodies (OR, 0.28; 0.13–0.64; p=0.01), and reduced levels of the complement 3 (OR, 0.30; 0.12–0.74; p=0.01) and 4 (OR, 0.44; 0.20–0.97; p=0.04) proteins were all significantly associated with AITD in SLE.

Upon adjustments for potential confounders, only serositis remained a significant risk factor for AITD in SLE (adjusted OR, 3.64; 1.65–8.04; p=0.00). On the other hand, the presence of anti-dsDNA antibodies seemed to have a significant protective effect (adjusted OR, 0.12–0.72; p=0.01).

The present study had important limitations, such as its retrospective design and the failure to screen all SLE patients for thyroiditis antibodies. In contrast, key strengths of the present study included the large study sample and the low interference from drugs, as participants were recruited before medication had been administered.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.