Most Read Articles
Dr. Joseph Delano Fule Robles, 6 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

5 days ago
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
5 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

Serious infection may improve survival in renal cell carcinoma

05 Nov 2017

Perioperative infection following nephrectomy appears to improve cancer-specific survival in patients with T2 (≥7 cm) renal cell carcinoma, according to a recent study.

Researchers conducted a retrospective cohort study using Surveillance, Epidemiology and End Results (SEER)-Medicare claims data from 2004 to 2011. They also used International Classification of Diseases (ICD)-9 and Current Procedural Terminology (CPT) codes to identify patients >65 years who underwent radical or partial nephrectomy for renal cell carcinoma.

Those hospitalized for infection within 30 days of surgery were identified. Patients who died within 90 days of surgery, had immunodeficiency and metastatic disease at diagnosis were not included.

Researchers used Kaplan-Meier curves to assess cancer-specific survival between infection and no infection groups. A Cox proportional hazards models was developed to evaluate survival while controlling for age, gender, race, Elixhauser index, tumour grade, tumour size, histological subtype, American Joint Committee on Cancer stage, systemic therapy and geographic region.

A total of 8,967 patients were identified. Of these, 493 (5.5 percent; median age 74 years; mean Elixhauser index, 4.9) were hospitalized for infection after nephrectomy, with a follow-up of 42 months.

Univariable Cox regression revealed a nonsignificant improvement in cancer-specific survival in patients with a serious infection requiring hospitalization following nephrectomy (hazard ratio [HR], 0.84; 95 percent CI, 0.69 to 1.00; p=0.054). In Cox multivariable regression, there was a significant improvement in cancer-specific survival for the same population (HR, 0.75; 0.57 to 0.99; p=0.04).

Such improvement was seen only in patients with larger (≥7 cm) tumours (HR, 0.67; 0.44 to 0.99; p=0.049). There was no impact found among patients with smaller (<7 cm) tumours (HR, 0.82; 0.57 to 1.19; p=0.3).

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Most Read Articles
Dr. Joseph Delano Fule Robles, 6 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

5 days ago
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
5 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.