Most Read Articles
Pearl Toh, 03 Jan 2020
Antibiotic resistance of Helicobacter (H.) pylori has more than doubled in Europe in the past two decades, raising alarm on the gravity of the issue of growing bacterial resistance to commonly-used antibiotics, a study presented at UEG Week 2019 has shown.
02 Dec 2019
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
3 days ago
The use of folic acid in addition to enalapril in the treatment of patients with hypertension yields a modest increase in lifetime stroke-free survival, a study has found.

Seniors on polypharmacy make more dosing errors over time

28 Dec 2019

Elderly adults taking multiple medications tend to make more and more dosing mistakes over time, a new study has found.

Enrolling in 2008, researchers followed 900 elderly adults (aged 55–74 years at baseline) for 9 years. At baseline, participants were given a standardized seven-drug regimen and were asked to demonstrate how they would take them over a 24-hour period. Dosing errors were recorded as a primary outcome, along with regimen consolidation.

A total of 303 participants (mean age, 62.6 years; 72.9 percent female) completed all medication dosing exercises over the 9-year follow-up period. At baseline, 98 percent of the sample had no cognitive impairment, which dropped slightly to 96 percent by the final follow-up, during which time one participant developed severe cognitive impairment.

At baseline, participants made an average of 2.9 dosing errors out of a total 21 potential errors. This climbed to a mean of 5.0 errors at the final follow-up, corresponding to a statistically significant increase (p<0.001). During both time points, spacing errors were the most prevalent (82.5 percent), followed by dose (33 percent) and frequency (16.8 percent) errors.

Multivariate analysis identified limited health literacy (p=0.01), meaningful cognitive decline (p=0.01) and a greater number of chronic conditions (p=0.01) as significant risk factors for changes in dosing errors over 9 years. Such errors at baseline were similarly predictive (p<0.001).  

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 03 Jan 2020
Antibiotic resistance of Helicobacter (H.) pylori has more than doubled in Europe in the past two decades, raising alarm on the gravity of the issue of growing bacterial resistance to commonly-used antibiotics, a study presented at UEG Week 2019 has shown.
02 Dec 2019
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
3 days ago
The use of folic acid in addition to enalapril in the treatment of patients with hypertension yields a modest increase in lifetime stroke-free survival, a study has found.