Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Jairia Dela Cruz, 02 Oct 2018
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
Dr. Joseph Delano Fule Robles, 14 Sep 2018

The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.

07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.

Self-administered isoniazid, rifapentine noninferior to directly observed treatment of latent TB infection

10 Nov 2017

Self-administered, once-weekly isoniazid and rifapentine to treat latent tuberculosis infection is feasible in the United States, and this treatment can be used in similar settings when direct observation is not viable, suggests a new study.

A total of 1,002 adults (median age 36 years; 48 percent women; 77 percent enrolled at the US sites) from outpatient tuberculosis clinics in the US, Spain, Hong Kong and South Africa received once-weekly isoniazid and rifapentine by direct observation, self-administration with monthly monitoring, or self-administration with weekly text message reminders and monthly monitoring.

Treatment completion, defined as 11 or more doses within 16 weeks and measured using clinical documentation and pill counts for direct observation, and self-reports, pill counts and medication event-monitoring devices for self-administration, was the primary outcome. The secondary outcomes were adverse events.

Treatment completion was highest in the direct-observation group at 87.2 percent (95 percent CI, 83.1 to 90.5 percent), followed by 76.4 percent (71.3 to 80.8 percent) in the self-administration‒with‒reminders group and 74.0 percent (68.9 to 78.6 percent) in the self-administration group.

In the US, treatment completion was 85.4 (80.4 to 89.4), 76.7 (70.9 to 81.7 percent) and 77.9 (72.7 to 82.6 percent), respectively. Self-administered therapy without reminders was noninferior to direct observation in the US, and no other comparisons met the noninferiority criteria.

There were a few and similar drug-related adverse events across all groups.

“Expanding latent tuberculosis treatment is important to decrease active disease globally. Once-weekly isoniazid and rifapentine for 12 doses is effective but limited by requiring direct observation,” researchers said.

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Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Jairia Dela Cruz, 02 Oct 2018
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
Dr. Joseph Delano Fule Robles, 14 Sep 2018

The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.

07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.