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Selenium supplementation beneficial to pregnant women with thyroiditis

10 Feb 2020

Pregnant women with thyroiditis may do well with selenium supplementation, which confers benefits for autoantibody titre during pregnancy and thyroiditis recurrence postpartum, as shown in a study.

A total of 45 women (mean age, 33.3 years; mean body mass index [BMI], 23.5 kg/m2) with thyroiditis in pregnancy were randomized to receive L-selenomethionine (L-Se-Met) 83 mcg/day or placebo. Researchers conducted evaluations at 10 and 36 weeks of gestation (T1 and T2, respectively) and 6 months after delivery.

At T1, 32 women were already taking levothyroxine while three initiated treatment. Ten women required a dosage adjustment during pregnancy, and another ten reduced dosage after delivery. None of the women stopped the therapy.

Autoantibody levels dropped significantly from baseline to after pregnancy in the L-Se-Met group (TgAb: 19.86; p<0.01; TPOAb: 255.00; p<0.01) but increased substantially in the placebo group (TgAb: 151.03; p<0.01; TPOAb: 441.28; p<0.01).

Selenemia significantly increased from baseline in the group of women who received selenium supplementation at T2 (91.33; p<0.01) and at postpartum (93.55; p=0.02).

Two women in the placebo group had a miscarriage. Thyroid volume, echogenicity, quality of life, maternal/foetal complications did not significantly differ between the two treatment groups.

The present data suggest that selenium supplementation during pregnancy and after delivery is safe and exerts beneficial effects in women with thyroiditis, according to researchers.

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Most Read Articles
01 Apr 2020
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).