Most Read Articles
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Roshini Claire Anthony, 24 Apr 2020

The gap in overall life expectancy between people with HIV (PWH) and those without HIV has narrowed over time, particularly among optimally treated PWH. However, PWH still have fewer comorbidity-free years than those without HIV, according to a study presented at CROI 2020.

Sedentary lifestyle, male sex tied to apnoeic–hypopnoeic events in OSA

16 Jan 2020

Awareness of the risk factors for residual apnoeic–hypopnoeic events can improve the timely delivery of personalized care for patients with obstructive sleep apnoea (OSA), including the type of positive airway pressure (PAP) therapy, attention to comorbidities and choice of interface, a study has shown.

The analysis included patients from the prospective French sleep apnoea registry diagnosed with OSA (apnoea–hypopnoea index [AHI] ≥15 events/h) treated with continuous (C)PAP. Factors associated with a risk of residual AHI >5 events/h on CPAP were identified by logistic regression analysis.

A total of 12,285 OSA patients were included, most of which were men (n=8,715; 70.9 percent), middle-aged (58.2 years) and obese (median body mass index, 31.1 kg/m2). Majority of the patients (n=9,573; 77.9 percent) had an AHI ≤5 events/h compared with 22.1 percent with AHI >5 events/h. The latter had less adherence to CPAP therapy (5.75 vs 6.00 h/night).

Multivariable analysis revealed that residual AHI >5 events/h was associated with age, male sex, sedentary lifestyle, OSA severity, cardiovascular comorbidities (eg, heart failure and arrhythmia) and type of interface (ie, orofacial mask vs nasal mask: odds ratio, 2.15, 95 percent confidence interval [CI], 1.95–2.37). In subgroup analysis, patients using pressures >10 cm H2O were 1.43 (95 percent CI, 1.3–1.57) times more likely to have residual AHI >5 events/h.

“CPAP is the first-line therapy for OSA,” the authors said. “Residual apnoea and/or hypopnea events … during CPAP contribute to treatment dropout.”

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Most Read Articles
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Roshini Claire Anthony, 24 Apr 2020

The gap in overall life expectancy between people with HIV (PWH) and those without HIV has narrowed over time, particularly among optimally treated PWH. However, PWH still have fewer comorbidity-free years than those without HIV, according to a study presented at CROI 2020.