Most Read Articles
23 Nov 2018
Initial acute respiratory illness (ARI) admissions related to human adenovirus (HAdV), human metapneumovirus (hMPV) and human rhinovirus (HRV) occurring during early infancy increase the risk of subsequent ARI-related readmission, a recent study has shown.
Jairia Dela Cruz, 08 Jan 2020
In chronic obstructive pulmonary disease (COPD) patients initiating inhaled corticosteroid (ICS)/long-acting β2 agonist (LABA) combinations, both budesonide/formoterol (FOR) dry-powder inhalers and beclomethasone/FOR metered-dose inhalers pose lower risks of severe pneumonia and severe adverse events compared with fluticasone/salmeterol delivered using the same type of inhaler, as reported in a recent study.
Rachel Soon, 04 Jan 2019

A new cell-cultured quadrivalent influenza vaccine may give Malaysian patients an alternative to those produced with traditional egg-based processes.

09 Nov 2019
Drinking soft drinks may be linked to asthma in adults and wheeze in children, according to a meta-analysis. Furthermore, prenatal maternal consumption of the drink can promote the development of inflammatory disease of the airways of the lungs in the offspring.

Sedentary lifestyle, male sex tied to apnoeic–hypopnoeic events in OSA

16 Jan 2020

Awareness of the risk factors for residual apnoeic–hypopnoeic events can improve the timely delivery of personalized care for patients with obstructive sleep apnoea (OSA), including the type of positive airway pressure (PAP) therapy, attention to comorbidities and choice of interface, a study has shown.

The analysis included patients from the prospective French sleep apnoea registry diagnosed with OSA (apnoea–hypopnoea index [AHI] ≥15 events/h) treated with continuous (C)PAP. Factors associated with a risk of residual AHI >5 events/h on CPAP were identified by logistic regression analysis.

A total of 12,285 OSA patients were included, most of which were men (n=8,715; 70.9 percent), middle-aged (58.2 years) and obese (median body mass index, 31.1 kg/m2). Majority of the patients (n=9,573; 77.9 percent) had an AHI ≤5 events/h compared with 22.1 percent with AHI >5 events/h. The latter had less adherence to CPAP therapy (5.75 vs 6.00 h/night).

Multivariable analysis revealed that residual AHI >5 events/h was associated with age, male sex, sedentary lifestyle, OSA severity, cardiovascular comorbidities (eg, heart failure and arrhythmia) and type of interface (ie, orofacial mask vs nasal mask: odds ratio, 2.15, 95 percent confidence interval [CI], 1.95–2.37). In subgroup analysis, patients using pressures >10 cm H2O were 1.43 (95 percent CI, 1.3–1.57) times more likely to have residual AHI >5 events/h.

“CPAP is the first-line therapy for OSA,” the authors said. “Residual apnoea and/or hypopnea events … during CPAP contribute to treatment dropout.”

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Most Read Articles
23 Nov 2018
Initial acute respiratory illness (ARI) admissions related to human adenovirus (HAdV), human metapneumovirus (hMPV) and human rhinovirus (HRV) occurring during early infancy increase the risk of subsequent ARI-related readmission, a recent study has shown.
Jairia Dela Cruz, 08 Jan 2020
In chronic obstructive pulmonary disease (COPD) patients initiating inhaled corticosteroid (ICS)/long-acting β2 agonist (LABA) combinations, both budesonide/formoterol (FOR) dry-powder inhalers and beclomethasone/FOR metered-dose inhalers pose lower risks of severe pneumonia and severe adverse events compared with fluticasone/salmeterol delivered using the same type of inhaler, as reported in a recent study.
Rachel Soon, 04 Jan 2019

A new cell-cultured quadrivalent influenza vaccine may give Malaysian patients an alternative to those produced with traditional egg-based processes.

09 Nov 2019
Drinking soft drinks may be linked to asthma in adults and wheeze in children, according to a meta-analysis. Furthermore, prenatal maternal consumption of the drink can promote the development of inflammatory disease of the airways of the lungs in the offspring.