Sedentary behaviour ups risk of functional limitation in adults with knee OA

23 Sep 2021
Sedentary behaviour ups risk of functional limitation in adults with knee OA

Being inactive (zero 10-min bouts/week in moderate-to-vigorous physical activity [MVPA]) is associated with a higher risk of developing functional limitation in adults with knee osteoarthritis (OA), regardless of sedentary category, a study has found.

The investigators classified participants into active-low sedentary (≥1 10-min bout/week of MVPA, lowest tertile for standardized sedentary time), active-high sedentary (≥1 10-min bout/week of MVPA, top 2 tertiles), inactive-low sedentary (zero 10-min bouts/week of MVPA, lowest tertile), and inactive-high sedentary (zero 10-minute bouts/week of MVPA, top 2 tertiles) groups using 48-month (baseline) accelerometry data from the Osteoarthritis Initiative.

Functional limitation was defined as >12 seconds for the 5-repetition sit-to-stand test (5XSST) and <1.22 m/s gait speed during the 20-metre walk test. The investigators assessed the association between exposure groups and the risk of developing functional limitation 4 years later by calculating adjusted risk ratios (ARR; adjusted for potential confounders).

A total of 1,091 and 1,133 participants had no baseline functional limitation based on the 5XSST and 20-metre walk test, respectively, of whom 15 percent and 21 percent developed functional limitation 4 years later.

The risk of developing functional limitations was higher in the inactive-low and inactive-high sedentary groups than in the active-low and active-high sedentary groups. The risk of developing functional limitation based on the 5XSST and 20-metre walk test was higher by 72 percent (ARR, 1.72, 95 percent confidence interval [CI], 1.00–2.94) and 52 percent (ARR, 1.52, 95 percent CI, 1.03–2.25), respectively, in the inactive-low sedentary group compared with the active-low sedentary group.

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