Sedentary behaviour tied to impaired kidney function
It appears that greater sedentary time is independently associated with reduced estimated glomerular filtration rate (eGFR), and this association is stronger in the presence of diabetes and arthritis, a study reports.
The cross-sectional study included 8,444 adults participating in the Canadian Health Measures Survey. Data on eGFR was examined in relation to sedentary time (total sedentary minutes divided by total wear time) measured using triaxial accelerometry. Multivariable ordinal logistic and linear regression were applied in the analyses.
Mean proportion of wear time spent sedentary was 80.7 percent in the most sedentary quartile (Q4), 74 percent in Q3, 68 percent in Q2 and 58 percent in Q1. Factors independently associated with a greater proportion of sedentary time included lower eGFR, older age, lower serum albumin level, higher blood pressure, cardiovascular disease, diabetes and higher body mass index.
Patients with eGFRs <45 mL/min/1.73 m2 had higher odds of being sedentary (odds ratio [OR], 4.2; 95 percent CI, 2.5–7.3). In the subgroup of patients with chronic kidney disease (CKD), greater sedentary time showed an association with diabetes (OR, 2.68; 1.56–4.59) and arthritis (OR, 2.32; 1.43–3.77).
Researchers pointed out that the mechanism underlying the association between reduced eGFR and greater sedentary time is likely multifactorial. In individuals with advanced and even earlier stages of CKD, the increased prevalence of sedentary behaviour may be explained by physiologic changes in muscle. Cognitive impairment and frailty may also contribute to increased sedentary status in individuals with impaired kidney function.
The present data underscore the need for prospective studies to determine the potential beneficial effects of sedentary behaviour reduction strategies on long-term clinical outcomes in this population, they added.