Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.

Secukinumab safe, effective for moderate-to-severe plaque psoriasis

15 Jul 2019

Secukinumab is safe and effective for the treatment of moderate-to-severe plaque psoriasis, with effects lasting up to a year after treatment initiation, reports a recent study.

A total of 158 patients (mean age, 28±17.7 years; 57 percent male) were included in the multicentre, prospective, observational study. All patients presented with moderate-to-severe plaque psoriasis and received secukinumab. Follow-ups were conducted every 12 weeks for 52 weeks.

More than a third (34.8 percent; n=55) of the participants had psoriatic arthritis, while 41.8 percent (n=66) and 34.2 percent (n=54) were smokers and drinkers, respectively. Almost half (44.9 percent; n=71) had body mass index >30 kg/cm2 and were characterized as obese.

After 52 weeks, majority (82.9 percent; n=131) of the patients were still on secukinumab and only 27 (17.1 percent) had discontinued treatment. Reasons for discontinuation included lack of efficacy (n=8), loss of efficacy (n=15) and loss to follow-up (n=4).

At week 4, 57 percent of the participants achieved 75-percent reduction in their baseline scores in the Psoriasis Area and Severity Index (PASI). This grew to 83.5 percent and 89 percent at weeks 12 and 24, respectively, before dropping back down to 78.5 percent by week 52.

In comparison, 27.8 percent achieved a 90-percent drop in their baseline PASI scores (PASI-90) by week 4, growing to 62 percent and 64.6 percent by weeks 12 and 24. PASI-90 was at 63.2 percent at the end of the intervention period.

Only 28 participants (17.7 percent) experienced adverse events over the course of the study, the most common of which were headaches and nasopharyngitis (n=9 each; 5.7 percent). Hypertension (n=6; 3.8 percent), oral candidiasis (n=5; 3.2 percent) and diarrhoea (n=2; 1.3 percent) were other such events.

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.