Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.

Second-line IAGC injection safe, effective for persistent Lyme arthritis in children

09 Aug 2019

Intra-articular glucocorticoid (IAGC) injection is associated with rapid clinical resolution and reduced need for additional treatment, making it an effective and safe second-line strategy for persistent Lyme arthritis in children, a recent study has shown.

Eighteen of the 112 children with persistently active Lyme arthritis after first-line antibiotics were treated with second-line IAGC (13 with concomitant oral antibiotics).

Compared to children treated with second-line oral antibiotics, those who received IAGC had similar baseline characteristics but lower rates of antibiotic-refractory Lyme arthritis (ARLA; 17 percent vs 44 percent; odds ratio, 0.3, 95 percent CI, 0.1–0.95; p=0.04) and faster rates of clinical resolution (hazard ratio, 2.2, 1.2–3.9; p=0.01).

Treatment-related adverse events were similar between children in IAGC and those on oral antibiotics.

Outcomes were similar among children treated with second-line IAGC regardless of concomitant antibiotics use. Intravenous and oral antibiotic-treated cohorts also showed similar outcomes, but older children appeared to be more favourably responsive to IV therapy. However, IV antibiotics correlated with higher toxicity rates.

This study sought to determine whether second-line IAGC injection improved outcomes in children with persistent Lyme arthritis after initial antibiotics. An observational comparative effective study was conducted through chart review within three paediatric rheumatology centres with distinct clinical approaches to second-line treatment of Lyme arthritis.

Children treated with second-line IAGC were compared to those receiving a second course of antibiotics monotherapy. The authors examined the risk of developing ARLA using logistic regression and the time to clinical resolution of Lyme arthritis using Cox regression.

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Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.