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Pearl Toh, 15 Jul 2019
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’Gamat‘ extract comparable to hydrogels for wounds

Rachel Soon
Medical Writer
20 Mar 2019

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

Researchers from Hospital Universiti Science Malaysia (HUSM) compared the effectiveness of a 15% S. horrens-based gel versus conventionally used hydrogel on wound healing rates, pain and pruritus on 25 human split-skin graft donors over 21 days. No significant differences were observed in re-epithelialization of the wounds, pain scores or pruritus scores (p<0.01) between the two treatments. [Complement Ther Med 2018;41:261–266]

“This is consistent with other hydrogel treated skin graft donor site wound studies done previously,” noted Dr Adzim Poh, main study author. “We also confirmed low adverse effects as stated by other studies.”

Gamat (which refers to multiple species of sea cucumber) is an ingredient of traditional medicine which is widely used in multiple Southeast Asian countries as a topical treatment for wounds and pain. Those of the Stichopus genus are most commonly used in the consumer market. [Malayan Nat J 2010;62:315–334]

According to Poh and colleagues, gamat extracts contain a rich nutrient composition, including essential amino acids, high polyunsaturated and monounsaturated fatty acids, all of which may play a role in tissue repair. S. horrens in particular contains eicosapentaenoic acid, which may initiate wound healing by prostaglandin inhibition and blood-clotting activity. [Gen Pharmacol Vasc Syst 1999;33:337–340]

The gel tested was comprised of 15% gamat liquid, imidazolidinyl urea, paraben mix, emulsifiers, a gelling agent, a pH modifier and purified water. Poh added that further studies might be needed to assess the effect of different concentrations of S. horrens extract, as well as its effect on deeper, full-thickness wounds.

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Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.