Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Screening for Alzheimer’s and related dementias has minimal effect in older adults

19 Dec 2019

Screening for Alzheimer’s disease and related dementias (ADRD) in older adults does not improve health-related quality of life (HRQoL), though it also does not seem to cause additional harm, a recent study has found.

Researchers conducted a single-blinded, two-arm, randomized controlled trial including 4,005 elderly patients (mean age, 74.1±6.9 years; 66 percent female) receiving primary care. Participants were assigned to receive either ADRD screening (n=2,008) or a control intervention (n=1,997). Screening was performed using the Memory Impairment Screen or the Mini-Cog tool.

HRQoL was comparable between groups after 12 months. Both the screening and control arms had a Health Utilities Index (HUI) score of 0.68 (effect size, 0.009, 95 percent confidence interval [CI], –0.063 to 0.080; p=0.81). Baseline scores were 0.67 in either group and were likewise statistically comparable.

HUI scores were similarly comparable at the 1-month (0.71 vs 0.69; mean difference, 0.014, 95 percent CI, –0.004 to 0.031; p=0.13) and 6-month (0.69 vs 0.70; mean difference, –0.003, 95 percent CI, –0.022 to 0.015; p=0.73) follow-ups between the screen and control groups.

This lack of clear benefit was matched by a lack of negative effects. Depressive symptoms, as measured by the Patient Health Questionnaire-9, were comparable between the screening and control arms at month 12 (mean scores: 2.74 vs 2.82; mean difference, –0.185, 95 percent CI, –0.393 to 0.025). The same null difference was reported at baseline, 1 month and 6 months.

Participants who were screened for ADRD likewise did not show elevated anxiety symptoms at 12 months, as by the Generalized Anxiety Disorder scale (screen vs control mean scores: 1.31 vs 1.45; mean difference, –0.164, 95 percent CI, –0.329 to 0.002).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.