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SBRT reduces acute toxicities in Asians with early-stage prostate cancer

Christina Lau
28 Nov 2018
Dr Darren Poon

Stereotactic body radiotherapy (SBRT) is associated with significantly lower rates of acute gastrointestinal (GI) and genitourinary (GU) toxicities compared with conventional fractionated intensity-modulated radiotherapy (CF-IMRT) in Asian patients with early-stage localized prostate cancer.

These results, from a randomized phase II study (n=64) reported at the European Society for Medical Oncology (ESMO) Asia 2018 Congress, suggest that SBRT (5 fractions) is a safe treatment option for Asians with low- or intermediate-risk localized prostate cancer when compared with CF-IMRT (38 fractions). [Poon DMC, et al, ESMO Asia 2018, abstract 218P]

“Patients in the SBRT group had significantly lower rates of grade ≥1 acute GI toxicities and grade ≥2 acute GU toxicities than those in the CF-IMRT group [35 percent vs 87 percent (p<0.0001) and 3 percent vs 24 percent (p=0.0426), respectively],” reported Dr Darren Poon of the Chinese University of Hong Kong. “No grade ≥3 acute toxicities were reported in either group.”
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Most Read Articles
3 days ago
A direct switch to indacaterol/glycopyrronium (IND/GLY) from salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with up to one exacerbation in the previous year improves predose forced expiratory volume in 1 s (FEV1) and forced vital capacity without presenting new safety signals, a recent study has found.