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26 Nov 2019
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SBP variation predicts outcomes in subarachnoid haemorrhage

6 days ago

Variations in systolic blood pressure (SBP) in the first 24 hours after admission appear to be linked to outcomes in patients with acute spontaneous subarachnoid haemorrhage (SAH), a recent study has found.

The study included 303 SAH patients (mean age, 57.04±12.53 years; 51.16 percent female) whose BP values were recorded upon admission and every 2 hours thereafter for the first 24 hours. BP variation was defined as the standard deviation (SD) of measurements, the difference between the maximum and minimum values (delta), the coefficient of variation (CV), and the successive variation (SV).

Majority (59.08 percent) of the study sample had favourable outcomes, as determined by the Glasgow Outcome Scale (GOS), earning scores from 4–5. The remaining 40.92 percent scored between 1–3 and were identified to have unfavourable outcomes.

Multivariable logistic regression analysis found that the topmost tertiles of all four SBP variation parameters were significantly predictive of outcome: delta (odds ratio [OR], 4.4, 95 percent confidence intervals [CI], 1.6–11.9; p<0.001), SD (OR, 13.9, 95 percent CI, 4.8–40.8; p<0.001), CV (OR, 16.4, 95 percent CI, 5.6–48.4; p<0.001) and SV (OR, 15.8, 95 percent CI, 5.3–46.9; p<0.001).

The same was true for SBP variation values in the second tertile, though with generally lower magnitudes of effect.

Moreover, maximum (OR, 10.2, 95 percent CI, 2.6–40.4; p=0.001) and mean (OR, 2.8, 95 percent CI, 1.1–6.9; p=0.024) SBP values emerged as significant predictors of the GOS outcome.

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Most Read Articles
26 Nov 2019
Hypertension is associated with a high cardiovascular disease burden but does not appear to have any impact on symptoms or functional capacity during exercise treadmill test (ETT) in patients with aortic stenosis, results of a study have shown.
28 Nov 2019
Slideshow: Highlights from the American Heart Association (AHA) Scientific Sessions 2019
Elaine Soliven, 27 Nov 2019
High levels of trunk fat mass (FM) may be associated with an increased risk of cardiovascular disease (CVD)-related events such as coronary death, nonfatal myocardial infarction, or coronary heart disease in postmenopausal women with normal body mass index (BMI), according to a recent study presented at AHA 2019.
28 Oct 2019
The C-reactive protein (CRP)-to-albumin ratio (CAR) appears to be linked to the development of acute kidney injury in patients with ST elevation myocardial infarction (STEMI), a recent study has found.