SBP inversely tied to depression, anxiety in young adults
An inverse association exists between systolic blood pressure (SBP) in young adults and depression and anxiety score, independent of a range of lifestyle confounders, according to a recent study. Furthermore, the inverse association between SBP and self-reported history of depression is enhanced by adiposity despite a positive correlation between BP and body mass index (BMI).
Researchers analysed data on 1,014 participants aged 20 years from the Western Australian Cohort (Raine) Study for cross-sectional associations between clinic BP and Depression, Anxiety, Stress Scale questionnaire scores or a reported history of depression, accounting for relevant confounders.
Multivariable adjusted analyses revealed that SBP in young adults was inversely associated with depression (coefficient=‒0.10; p=0.012) and anxiety (after excluding two outliers with SBP >156 mm Hg, coefficient=‒0.13; p=0.018) scores, independent of sex, BMI, female hormonal contraceptive use, alcohol consumption, birth weight and maternal hypertension in pregnancy.
For every 2-SD (16 units) increase in depression score, SBP was lower by 1.6 mm Hg. Moreover, an inverse relationship was found between self-reported history of depression (15.8 percent of participants) and SBP (coefficient=‒1.91; p=0.023), with an interaction with increasing BMI (coefficient=‒0.43; p=0.002) enhancing this difference.
“These findings contrast with the predisposition of depressed participants to cardiovascular disease in later life when decades of unhealthy lifestyle changes may dominate,” researchers said.
In a previous study, Tikhonoff and colleagues found that a cumulative effect of symptoms of anxiety and depression across adulthood led to lower SBP in late middle age that was not explained by lifestyle factors and antihypertensive treatment. [J Hypertens 2014;32:1590-8]