Most Read Articles
17 Apr 2019
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
Yesterday
A recent study has demonstrated the potential of clindamycin as a treatment alternative to antibiotic combination regardless of hidradenitis suppurativa (HS) clinical stage.
Pearl Toh, 17 Apr 2019
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.
Roshini Claire Anthony, 2 days ago

Men with advanced prostate cancer who have pre-existing cardiovascular disease (CVD) may have an elevated mortality risk after treatment with abiraterone acetate compared with men who do not have CVD, according to a study presented at AACR 2019.

Sarilumab shows promise in treatment of noninfectious uveitis of posterior segment

08 Nov 2018

Subcutaneous sarilumab shows therapeutic potential in the management of noninfectious uveitis affecting the posterior segment of the eye, especially eyes with uveitic macular oedema, according to the results of the phase II SATURN trial.

SATURN randomly assigned (2:1) 58 eyes of adult patients with noninfectious intermediate, posterior or panuveitis to treatment with subcutaneous sarilumab 200 mg or placebo administered every other day for 16 weeks.

At week 16, the primary endpoint of proportion of patients with ≥2-step reduction in vitreous haze (VH) did not significantly differ between the sarilumab and placebo arms (mean, 46.1 percent vs 30.0 percent; p=0.2354). The alternate primary endpoint of corticosteroid dose <10 mg/day was better in the former arm (mean, 64.0 percent vs 35.0 percent; p=0.0372).

In the subgroup of eyes VH grade 2 or higher at baseline, VH decreased significantly with sarilumab vs placebo at week 16 regardless of assessment by central reading centre (mean, –2.1 vs –1.7; p=0.0255) or investigator (–2.5 vs –1.2; p=0.0170).

Sarilumab was also superior to placebo in terms of mean best-corrected visual acuity gain from baseline to week 16 in the overall population (8.9 vs 3.6 letters; p=0.0333) and in the subgroup of eyes with central subfield thickness (CST) ≥300 μm at baseline (12.2 vs 2.1 letters; p=0.0517). Corresponding changes in CST were –46.8 vs 2.6 μm (p=0.0683) in the overall population and –112.5 vs –1.8 μm (p=0.1317) in the subgroup of eyes with CST ≥300 μm at baseline, respectively.

Commonly reported ocular adverse events included worsening of uveitis and retinal infiltrates.

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Most Read Articles
17 Apr 2019
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
Yesterday
A recent study has demonstrated the potential of clindamycin as a treatment alternative to antibiotic combination regardless of hidradenitis suppurativa (HS) clinical stage.
Pearl Toh, 17 Apr 2019
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.
Roshini Claire Anthony, 2 days ago

Men with advanced prostate cancer who have pre-existing cardiovascular disease (CVD) may have an elevated mortality risk after treatment with abiraterone acetate compared with men who do not have CVD, according to a study presented at AACR 2019.