Most Read Articles
13 Mar 2017
The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
Clare Cuckson, 01 Jun 2012
During pregnancy, there is generalized relaxation of smooth muscle resulting in relaxa¬tion of the oesophageal sphincter, reduced gastric peristalsis, and delayed gastric emp¬tying. Small and large bowel transit times are increased. There is increased blood flow to the liver and increased production of fibrinogen, transferrin and many other binding proteins. Reference ranges for many liver function tests are altered. Gestation-specific alkaline phosphatase is increased, mainly from increased placental production, and aminotransferases and γ-glutamyltransferase are reduced.

 

Saline irrigation of the bile duct prevents residual stones

14 Apr 2018
Those with a history of gallstone disease have a 23% increased risk for coronary heart disease.

Preventive saline irrigation of the bile duct (PSIB) appears to be effective in reducing residual stones after endoscopic common bile duct stone (CBD) removal, according to a recent study.

Researchers randomized 148 patients who underwent endoscopic retrograde cholangiopancreatography to either receive (n=73) or not receive (n=75) PSIB after stone removal. Presence of residual stones was evaluated within 6 months after the operation.

Residual stones were reported in 14.9 percent (n=22), five of whom received PSIB (6.8 percent) while 17 did not (22.7 percent). The difference in residual stone incidence rate reached statistical significance (p=0.01).

Multivariate logistic regression analysis revealed that PSIB had a significant protective effect against residual stones following CBD removal (odds ratio [OR], 0.09; 95 percent CI, 0.02–0.45; p=0.003). In contrast, the presence of multiple CBD stones significantly increased the risk of residual stones (OR, 9.40; 1.86–47.54; p=0.007).

A subsequent subgroup analysis showed that PSIB had greater efficacy against residual stones in patients with multiple CBD stones (rate of residual stones, 12.1 percent in PSIB group vs 50.0 percent in non-PSIB group).

The rate of procedure-related complications was 12.8 percent (n=19), the most common of which was pancreatitis. There was no significant difference in the number of patients who experienced complications in the PSIB vs non-PSIB groups (p=0.793). The rate of cholangitis was slightly higher in the PSIB group (5.5 percent vs 2.7 percent), and all patients were given conservative management.

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Most Read Articles
13 Mar 2017
The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
Clare Cuckson, 01 Jun 2012
During pregnancy, there is generalized relaxation of smooth muscle resulting in relaxa¬tion of the oesophageal sphincter, reduced gastric peristalsis, and delayed gastric emp¬tying. Small and large bowel transit times are increased. There is increased blood flow to the liver and increased production of fibrinogen, transferrin and many other binding proteins. Reference ranges for many liver function tests are altered. Gestation-specific alkaline phosphatase is increased, mainly from increased placental production, and aminotransferases and γ-glutamyltransferase are reduced.