Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Ruxolitinib cream provides relief for atopic dermatitis

30 May 2020

Ruxolitinib (RUX) creams appear to ease itch severity and improve quality of life (QoL) among patients with atopic dermatitis (AD), a new study has found.

Researchers randomly assigned 307 (median age, 35.0 years; 54.7 percent female) adult AD patients to receive 8 weeks of RUX, triamcinolone or vehicle creams. RUX was given in four doses: 1.5% twice-daily (BID), and 1.5%, 0.5%, 0.15% all once-daily (QD). Both passive and active controls were given BID. Itch, the primary study outcome, was measured using the numerical rating scale (NRS), while QoL was assessed using Skindex-16.

RUX cream 1.5% BID significantly reduced NRS itch scores within 36 hours relative to the vehicle comparator (–1.8 vs 0.2; p<0.0001).

Moreover, all RUX cream treatments led to reductions in itch NRS scores within the first 2 weeks of treatment, with effects persisting for the rest of the trial period. After 4 weeks of treatment, both BID (–64.6) and QD (–54.0) regimens of the 1.5% RUX cream yielded better itch relief than triamcinolone (–50.3). However, only the BID RUX regimen was statistically superior (p=0.003).

These symptomatic improvements coincided with better QoL. All RUX cream arms showed significant improvements relative to baseline. This was particularly true in the 1.5% BID regimen, where Skindex-16 scores improved by a mean of 63.5 percent and 73.2 percent at weeks 2 and 8, respectively. In comparison, vehicle participants only saw QoL improvements of 10.5-percent and 19.7-percent at these corresponding timepoints.

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Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.