Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Ruxolitinib cream ineffective against alopecia areata

16 Feb 2020

A 1.5% ruxolitinib cream does not seem to be effective for patients with alopecia areata (AA), a recent phase II study has found.

The present study occurred over two parts. In the first, researchers conducted an open-label, 24-week trial of 1.5% ruxolitinib cream on 12 AA patients with 25–99 percent hair loss, followed by an extension period. The second part was a double-blind, vehicle-controlled study on 78 AA patients with 25–100 percent hair loss. This was followed by a crossover to ruxolitinib by the vehicle group.

In the first part, 25.0 percent (n=3) of the participants achieved at least a 50-percent improvement in the Severity of Alopecia Tool (SALT50) by week 12. Another patient met this endpoint by week 18. By the end of the study at week 24, half of the population (n=6) had met SALT50.  

The extension phase included nine patients, four of whom were at SALT50, and lasted for mean of 57.5 weeks. At week 48, one patient who had SALT50 further improved to SALT90 and another discontinued the study. None of those who were not at SALT50 at the beginning of the extension phase achieved SALT50 by its end.

In the second part, two ruxolitinib patients (5.1 percent) achieved SALT50 as early as week 8 and, by 24 weeks, this number increased to five patients (12.8 percent); over this time period, the same number of vehicle participants achieved SALT50. The between-group difference was nonsignificant (p=0.99).

Sixty-three patients continued on to the open-label period, with 32 crossing over to ruxolitinib cream treatment. Researchers found no statistical impact of the crossover on SALT50 and improvement in SALT scores from baseline.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.