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Roshini Claire Anthony, 02 Feb 2018

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Rosuvastatin improves coagulation profile of patients with prior thrombosis

Pearl Toh
17 Aug 2017

Rosuvastatin led to improved coagulation profile, in particular lower levels of factor VIII procoagulant activity (VIII:C), among patients who had venous thrombosis (VT) previously, suggesting that statins could reduce the risk of recurrent VT, according to a study presented at the ISTH 2017 Congress in Berlin, Germany.

The study randomized 247 participants (mean age 58 years, 62 percent women), with prior VT and who recently stopped their anticoagulant therapy, to receive rosuvastatin 20 mg/day for 4 weeks or no intervention. Five coagulation factors ─ factor VIII:C, factor VII:C, factor XI:C, von Willebrand factor (VWF:Ag), and D-dimer were measured through blood test at baseline and at the end of the study. [ISTH 2017, abstract LB03]

Mean factor VIII:C ─ the primary endpoint and for which the study was powered ─ was 7.2 IU/dL lower (95 percent confidence interval [CI], -11.5 to -2.9) than baseline in the rosuvastatin arm, while there was no change from baseline in the control arm (mean difference, -0.1 IU/dL, 95 percent CI, -3.0 to 2.9). 

After adjusting for age and sex, the reduction in factor VIII:C from baseline remained greater in rosuvastatin users vs nonusers (adjusted difference, -6.7 IU/dL, 95 percent CI, -12.0 to -1.4).

Among 52 rosuvastatin users with high factor VIII:C at baseline (>150 IU/dL), the elevated levels were normalized in 15 participants at the end of study, equivalent to a 12 percent decrease in the percentage of patients with elevated levels.

In contrast, the proportion of patients with high factor VIII:C levels was the same between baseline and end of study among nonusers.

For all the other coagulation factors tested, the mean coagulant activity from baseline was also lower or trended towards lower levels at the end of study in the rosuvastatin compared with the control arms.

“These results encourage conducting a randomized trial to determine whether statin therapy is a good alternative for long term anticoagulant treatment when it reduces the risk of recurrent VT without inducing bleeding,” according to the researchers.

The findings were in keeping with previous observational studies, which indicate that statins may reduce the risk of recurrent VT. One such study is the MESA* study, which showed that the levels of factor VIII, D-dimer, and C-reactive protein were lower among healthy participants who were on statins compared with those who did not take statins. [J Thromb Haemost 2013;11:1078-1084]

 

 

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Most Read Articles
Roshini Claire Anthony, 02 Feb 2018

The use of weight loss medications for at least 1 year did little to improve cardiometabolic risk factors in obese adults, according to a systematic review and meta-analysis.

17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
26 Feb 2019
Oral fluoxetine confers beneficial effects in the management of adult and adolescent amblyopia, suggests a recent study.
19 Feb 2019
Preprandial administration of metformin successfully and safely reduces postprandial plasma triglyceride levels, a new study has shown.