Most Read Articles
Pearl Toh, 29 Jun 2020
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6 days ago
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Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Rose Bengal photodynamic antimicrobial therapy an effective adjunct for progressive keratitis

28 Sep 2019

Use of Rose Bengal photodynamic antimicrobial therapy (RB-PDAT) in the adjunct setting shows promise in the management of severe, progressive infectious keratitis prior to a therapeutic keratoplasty, according to the results of a pilot trial.

A total of 18 patients (age range, 17–83 years; 61.1 percent female) with progressive infectious keratitis unresponsive to standard medical therapy underwent RB-PDAT at a single institution. RB-PDAT involved the application of a Rose Bengal solution (0.1% or 0.2% RB in balanced salt solution) to the de-epithelized cornea for 30 minutes, followed by irradiation with a 6 mW/cm2 custom-made green LED source for 15 minutes (5.4 J/cm2).

Acanthamoeba was the most common microbe detected (10/17; 59 percent), followed by Fusarium spp. (4/17; 24 percent), Pseudomonas aeruginosa (2/17; 12 percent) and Curvularia spp. (1/17; 6 percent); one patient had no confirmed microbiologic diagnosis. The chief clinical risk factor was contact lens wear (79 percent).

Prior to first RB-PDAT, the average area of epithelial defect was 32 mm2, while the average stromal depth hyper-reflectivity quantified via anterior segment optical coherence tomography was 269 μm.

RB-PDAT led to avoidance of therapeutic keratoplasty in 72 percent of patients. The average time to clinical resolution (defined as reduction in pain and inflammation with re-epithelization and infiltrate resolution) was 46.9 days. Duration of follow up after RB-PDAT was 13.3 months.

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Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.