Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Role of genomics in colorectal cancers

Dr Joslyn Ngu
04 Dec 2017

Advancements in genomics has paved the way for better classifications of colorectal cancers (CRC) and the use of precision therapy.

Colorectal cancer is not a single disease, but a set of molecularly distinctive diseases with the same clinical presentation, said Associate Professor Ho Gwo Fuang, clinical oncologist at the University Malaya Medical Centre. By stratifying patients into clinically relevant molecular subtypes, treatment can be more personalized. Genomics advancements has allowed for better risk stratification of early stage disease and these are carried out by gene signature profiling tools such as ColoPrint, Ocotype Dx and ColDx (now called GeneFx Colon).

There are four consensus molecular subtypes of CRCs: CSM1 to 4. CSM1 tumours are more commonly found in the proximal colon. Generally, they are poorly differentiated, of mucinous subtype and have dense lymphocytic infiltration. This indicates strong antitumoural immune response which makes good targets for immune checkpoint inhibitors. CSM 2 to 4 are usually located towards the distal part of the colon and rectum. CSM 2 and 3 tumours are immune-ignorant and CSM 4 tumours are immune-tolerant. The most common mutation pathways in CRC include APC, RAS and Wnt pathways. The last occurs in 93 percent of patients, he said.

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Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).