Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Robotic better than open salvage radical prostatectomy for recurrent prostate cancer

10 Oct 2019

Salvage radical prostatectomy results in better functional outcomes and has a low risk of major complications as compared to those previously reported, a study claims. Furthermore, robotic salvage radical prostatectomy appears to reduce anastomotic stricture, blood loss and hospital stay, and improve continence outcomes.

Of the 395 salvage radical prostatectomies included, 186 were open and 209 were robotic. The latter approach resulted in lower blood loss and a shorter hospital stay (p-each<0.0001). There was no significant difference in the incidence of major (10.1 percent; p=0.16) and overall complications (34.9 percent; p=0.67), including an overall low risk of rectal injury (1.58 percent) and fistula (2.02 percent).

The open approach, on the other hand, led to more frequent anastomotic stricture (16.57 percent vs 7.66 percent; p<0.01).

Severe incontinence, defined as use of 3 pads per day, occurred in 24.6 percent of patients for 12 or 6 months. Multivariable analysis revealed that robotic salvage radical prostatectomy independently predicted continence preservation (odds ratio, 0.411, 95 percent CI, 0.232–0.727; p=0.022).

In this study, the authors retrospectively collected data on salvage radical prostatectomy for recurrent prostate cancer after local nonsurgical treatment at 18 tertiary referral centres from 2000 to 2016. Complications were classified by applying the Clavien-Dindo classification. Univariable and multivariable analyses were performed to assess complications and functional outcomes.

The study was limited by its retrospective nature and the absence of a standardized surgical technique.

“Salvage radical prostatectomy has historically yielded a poor functional outcome and a high complication rate,” the authors said. “However, recent reports of robotic salvage radical prostatectomy have demonstrated improved results.”

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.