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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Rituximab superior to cyclophosphamide in AS-related ILD

28 Nov 2020

Treatment with rituximab (RTX) results in better 2-year progression-free survival (PFS) compared to cyclophosphamide (CYC) despite similar PFS at 6 months in patients with antisynthetase syndrome (AS)-related interstitial lung disease (ILD), a study has shown.

The investigators carried out this observational retrospective study in three tertiary care centres between 2003 and 2016. Sixty-two patients with AS-related ILD and treated with either RTX or CYC with at least 6 months of follow-up were included. PFS was defined according to the American Thoracic Society guidelines and assessed at 6 months and 2 years. All severe adverse events (AE) were recorded.

Of the patients, 34 received 2–12 monthly intravenous CYC pulses, followed by standard immunosuppressive treatment (IST) in 30 cases (88 percent), and 28 received RTX. Following the initial day 1 to 15 infusions, RTX was repeated every 6 months in 26 patients (93 percent), while 15 (54 percent) received another IST concomitantly. The two groups had similar median steroid dose.

RTX and CYC yielded comparable PFS at 6 months (92 percent and 85 percent, respectively), but the former was superior at 2 years (hazard ratio [HR], 0.263, 95 percent confidence interval [CI], 0.094–0.732; p=0.011).

Of note, lower diffusing lung capacity for carbon monoxide (DLCO) at baseline independently predicted poor 2-year PFS (HR, 0.965, 95 percent CI, 0.936–0.995; p=0.023). Both treatment groups had improvements in forced vital capacity and DLCO with no significant differences. Serious AEs were also comparable between RTX and CYC.

“AS-related ILD has a poor prognosis. Intravenous CYC and RTX are the main treatments currently used for moderate to severe ILD,” the investigators said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.