Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Stephen Padilla, 31 Jan 2020
The combination of ivermectin 1% cream (IVM) and doxycycline 40-mg modified-release capsules (DMR) delivers faster responses, better response rates and greater satisfaction compared with monotherapy in patients with severe rosacea, a recent study has shown.
26 Jun 2020
Dapagliflozin 5 mg and 10 mg FC tab
26 Jun 2020
Apalutamide 60 mg film-coated tab

Rituximab appears to be effective in systemic rheumatoid vasculitis

28 Apr 2020

Treatment with rituximab for systemic rheumatoid vasculitis (RV) results in complete remission (CR) in 62 percent of patients and partial response (PR) in 38 percent, a study has shown.

Medical charts of 17 patients (mean age, 59 years; 59 percent female) treated with rituximab for systemic RV from 2000 to 2017 were retrospectively reviewed. Analysis was performed on clinical characteristics, outcomes and adverse effects.

At RV diagnosis, 82 percent of patients had positive rheumatoid factor. Median Birmingham Vasculitis Activity Score for rheumatoid arthritis at the time of rituximab initiation was 4.0 (interquartile range, 2.0–7.5). Of the patients, eight (47 percent) presented with RV in the skin, two (12 percent) had mononeuritis multiplex, two (12 percent) experienced inflammatory ocular disease, and five (29 percent) had multiple organ systems affected by RV.

Rituximab was used for induction therapy in eight patients (47 percent), relapsing RV in four (24 percent), second-line therapy in two (12 percent), and salvage therapy or in combination with another medication in three (18 percent).

At 3 months, CR was achieved by two (13 percent) of 15 patients with available follow-up data and PR by 10 (67 percent). At 6 months, CR and PR were achieved by six (40 percent) and eight (53 percent) patients, whereas one showed no response. Eight (62 percent) of 13 patients with available records achieved CR and five (38 percent) had PR at 12 months.

“Further evidence is needed to inform treatment for patients with RV,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Stephen Padilla, 31 Jan 2020
The combination of ivermectin 1% cream (IVM) and doxycycline 40-mg modified-release capsules (DMR) delivers faster responses, better response rates and greater satisfaction compared with monotherapy in patients with severe rosacea, a recent study has shown.
26 Jun 2020
Dapagliflozin 5 mg and 10 mg FC tab
26 Jun 2020
Apalutamide 60 mg film-coated tab