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Risks of acute myocardial infarction, heart failure high in inflammatory bowel disease

24 May 2018

Patients with inflammatory bowel disease (IBD) are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.

A total of 736 IBD patients (339 with Crohn’s disease; 397 with ulcerative colitis) and 1,472 matched controls were followed for a total of 11,398 person-years and 17,880 person-years, respectively, for the development of AMI or heart failure.

On Cox proportional hazards analysis adjusted for traditional cardiovascular disease risk factors, IBD was independently associated with elevated risks of AMI (adjusted hazard ratio [aHR], 2.82; 95 percent CI, 1.98–4.04) and heart failure (aHR, 2.03; 1.36–3.03). The increase in the risk of these cardiovascular disorders was observed in both patients with Crohn’s disease (aHR vs controls, 2.89; 1.65–5.13) and ulcerative colitis (aHR vs controls, 2.70; 1.69–4.35).

When assessed separately, the risk of AMI was elevated in systemic corticosteroid users (aHR vs controls, 5.08; 3.00–8.81) and nonusers (aHR vs controls, 1.79; 1.08–2.98).

On the other hand, the risk of heart failure was significantly high in patients with ulcerative colitis (aHR, 2.06; 1.18–3.65) but not in those with Crohn’s disease, and in systemic corticosteroid users (aHR, 2.51; 1.93–4.57) but not in nonusers.

The present data should prompt close monitoring of IBD patients for the development of cardiovascular disorders, researchers said. Additional studies are needed to investigate whether controlling systemic inflammation could ultimately prevent AMI and heart failure in this population.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Pank Jit Sin, 07 Jun 2018
A reduction as small as 2 mm Hg can lower cardiovascular risks among patients with cardiovascular disease (CVD), says an expert.
01 Mar 2016
Teaching healthcare providers to execute a chest compression (CC) of 6-7 cm depth may enhance quality CC depth in patients on a mattress during cardiopulmonary resuscitation (CPR) in the hospital, based on a prospective, randomised, controlled study.
06 Jun 2018
Increased concentrations of omega-3 fatty acid (n-3 FA) appear to contribute to a clinically relevant reduction in blood pressure (BP) levels among normotensive young and healthy individuals, as shown by the results of a recent cross-sectional study.