Most Read Articles
05 Dec 2017
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
4 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.

Risk of VTE higher in patients with primary Sjögren syndrome

31 Aug 2017

Population-based evidence shows a substantially increased risk of venous thromboembolism (VTE) among patients with primary Sjögren syndrome (pSS), especially within the first year after SS diagnosis.

Researchers created a study cohort of all patients with incident SS using a population database that includes all residents of British Columbia, Canada, and up to 10 controls from the general population matched for age, sex and entry time to estimate the future risk and time trends of VTE in individuals with newly diagnosed PSS.

Incidence rates (IRs) of pulmonary embolism (PE), deep vein thrombosis (DVT) and VTE were compared between the two groups according to SS disease duration. Hazard ratio (HR) was also calculated, adjusting for confounders.

Of the 1,175 incident pSS cases (mean age 56.7 years; 87.6 percent women), the respective IRs of PE, DVT and VTE were 3.9, 2.8 and 5.2 per 1,000 person-years. The corresponding rates among controls were 0.9, 0.8 and 1.4 per 1,000 person-years.

In comparison with non-SS individuals, the multivariable HR among SS cases was 4.07 (95 percent CI, 2.04 to 8.09) for PE, 2.80 (1.27 to 6.17) for DVT and 2.92 (1.66 to 5.16) for VTE. The HR matched for age, sex and entry for VTE (8.29; 2.57 to 26.77), PE (4.72; 1.13 to 19.73) and DVT (7.34; 2.80 to 19.25) were highest during the first year after SS diagnosis.

According to researchers, further studies into the involvement of monitoring and prevention of VTE in SS may be warranted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
05 Dec 2017
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
4 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.