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Risk of readmission high in infants with viral acute respiratory illnesses

23 Nov 2018

Initial acute respiratory illness (ARI) admissions related to human adenovirus (HAdV), human metapneumovirus (hMPV) and human rhinovirus (HRV) occurring during early infancy increase the risk of subsequent ARI-related readmission, a recent study has shown.

Of the 1,941 participants included in the study, 1,254 (64.6 percent) were diagnosed with viruses at enrolment. HRV, respiratory syncytial virus (RSV), HAdV and hMPV were detected in 499 (25.7 percent), 439 (22.6 percent), 156 (8.0 percent) and 47 (2.4 percent) children, respectively.

Total ARI-related readmissions were 277 during the follow-up period (4,572.7 person-years). Virus-related ARI initial admission correlated with an elevated risk of ARI readmission for children who were initially admitted before 6 months of age (adjusted rate ratio [ARR], 1.6; 95 percent CI, 1.1–2.5). Independent associations of HAdV (ARR, 4.6; 1.8–11.9), hMPV (ARR, 20.4; 6.2–66.9) and HRV (ARR, 1.6; 1.0–2.4) with the outcome were observed.

Such associations did not exist for children whose initial admission occurred after 6 months of age.

In this study, the authors collected clinical information and nasopharyngeal swab samples from children <2 years old at their initial ARI admission in Vietnam from January 2007 to April 2012.

Comparisons were made on the incidence of ARI readmission during the follow-up period (initial admission to 5 years of age) between children with and without one of 13 respiratory viruses (influenza virus A, influenza virus B, RSV, hMPV, parainfluenza virus-1, parainfluenza virus-2, parainfluenza virus-3 and parainfluenza virus-4, HRV, human coronavirus-229E, human coronavirus-OC43, HAdV and human bocavirus) at initial admission.

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Pearl Toh, 10 Oct 2019
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