Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Risk of hospital-acquired disability greater at low physical activity levels

08 Dec 2019

Low levels of physical activity while in the hospital appears to increase the likelihood of hospital-acquired disability (HAD) in elderly adults, a recent study has shown.

Researchers conducted a prospective, observational assessment of 46 community-dwelling elderly adults (mean age, 73.2±9.5 years; 48 percent male) who were admitted to general medicine departments. The primary outcome was the development of HAD. An ankle accelerometer was used to measure hospital activity. Assessments were performed within 24 hours of admission.

Participants wore their accelerometers for a mean of 4.1±2.0 days, for an average of 16±2.8 hours per day. Devices were worn mostly during the daytime.

Almost half (n=19; 41 percent) of the participants developed HAD, 12 of whom (26 percent) self-reported declines in activities of daily living and scores in the Late-Life Function and Disability Instrument. Seven (15 percent) were discharged to a skilled nursing facility.

Daily activity time (0.8 vs 1.4 hours; p=0.04) and step counts (1,186 vs 1,808 steps; p=0.04) were both significantly lower in participants who developed HAD. Sedentary time had no apparent effect.

Almost a quarter of the participants (24 percent; n=11) walked less than 900 steps per day; more than half of this group (64 percent; n=7) developed HAD. The corresponding risk estimate was elevated but not statistically significant (odds ratio, 3.4, 95 percent confidence intervals, 0.82–13.8). At this threshold, step count had a sensitivity of 0.4 and specificity of 0.85 for predicting HAD.

“Further studies are needed to determine if higher step count thresholds can improve the sensitivity for the identification of hospitalized populations at increased risk for functional decline during hospitalization,” said the researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.