Most Read Articles
Christina Lau, 23 Nov 2018

In patients with severe small vessel disease (SVD), intensive blood pressure (BP) lowering does not reduce cerebral perfusion or increase the risk of falls, according to results of the ASL substudy of the PRESERVE trial.

29 Apr 2016
This article presents the excerpts from the Inaugural Meeting of the Dementia Advisory Board Malaysia held on 23 January 2016 in Kuala Lumpur, highlighting the clinical evidence of Ginkgo biloba extract EGb761® in dementia, treatment recommendations from international guidelines and consensus reached during the meeting on the role of EGb761® in managing dementia.
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.

Risk of dementia high before, after stroke

10 Oct 2018

The risk of dementia is elevated before and after an index stroke even in women, a recent study has found.

The study included 1,460 women (mean age 46.8±6.2 years) without stroke or dementia at baseline, and who were followed-up for 44 years. Neuropsychiatric examinations and informant interviews, as well as reviews of hospital registries and medical records, were used to identify the development of stroke or dementia.

A total of 362 participants developed first-onset stroke during 49,623 person-years of follow-up at a mean age of 77.8±8.7 years. In comparison, 325 cases of dementia were reported during 49,663 person-years at a mean age of 79.8±7.9 years. Mortality rates were 81 percent and 69 percent, respectively.

The cumulative incidence of prestroke dementia was 13.8 percent (n=50), majority of whom developed the neurological condition 5 years before the index stroke. Poststroke dementia was reported in 54 women (18.4 percent).

During 44 years of follow-up, 33.7 percent of women with a history of stroke developed dementia. This was significantly higher than in those without such history (18.5 percent; age-adjusted hazard ratio [HR] without competing risk, 1.44; 95 percent CI, 1.14–1.81). The age of dementia onset was similar in both groups (78.9±6.8 vs 77.3±7.8 years).

Notably, the increase in age-adjusted dementia risk achieved significance 5 years before the index stroke event (HR, 1.57; 1.03–2.40) and gradually increased to stroke onset (1 year before: HR, 2.65; 1.48–4.75; the same year: HR, 3.85; 2.37–6.26), reaching its peak during the year after stroke (HR, 4.17; 2.46–7.07).

The associated dementia risk remained significant 2–5 years after stroke event (HR, 1.78; 1.08–2.94).

Editor's Recommendations
Most Read Articles
Christina Lau, 23 Nov 2018

In patients with severe small vessel disease (SVD), intensive blood pressure (BP) lowering does not reduce cerebral perfusion or increase the risk of falls, according to results of the ASL substudy of the PRESERVE trial.

29 Apr 2016
This article presents the excerpts from the Inaugural Meeting of the Dementia Advisory Board Malaysia held on 23 January 2016 in Kuala Lumpur, highlighting the clinical evidence of Ginkgo biloba extract EGb761® in dementia, treatment recommendations from international guidelines and consensus reached during the meeting on the role of EGb761® in managing dementia.
Christina Lau, 23 Nov 2018

Use of a ginkgo biloba extract on top of standard preventive treatment is shown to improve cognitive function and overall condition after acute ischaemic stroke.