Most Read Articles
3 days ago
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Pearl Toh, 2 days ago
Whether the 2017 ACC/AHA* blood pressure (BP) guidelines should be adopted in Asian countries was the topic of a much-anticipated discussion here at the Asian Pacific Society of Cardiology (APSC) Congress 2018 in Taiwan last week.

Risk factors for CAD, stroke in adults with congenital heart disease

20 Sep 2017

Among ageing adult congenital heart disease (ACHD) patients, traditional atherosclerotic risk factors are associated with coronary artery disease (CAD), while ischaemic stroke is related to factors suggesting a cardioembolic aetiology, a multicentre case–control study has found.

Using the national CONgenital CORvitia (CONCOR) registry, researchers identified 6,904 ACHD patients, among whom 55 had CAD (mean age 55.1 years; 80 percent male) and 56 had stroke (mean age 46.9 years; 46 percent male).

Patients with CAD were matched 1:2 with ACHD patients without CAD based on age, CHD defect group and gender. Patients with ischaemic stroke (or transient ischaemic attack) were similarly matched. The presence of risk factors was determined using medical charts and a standardized questionnaire.

Multivariable logistic regression analysis showed CAD to be associated with traditional atherosclerotic risk factors, such as hypertension (odds ratio [OR], 2.45; 95 percent CI, 1.15 to 5.23), hypercholesterolaemia (OR, 3.99; 1.62 to 9.83) and smoking (OR, 2.25; 1.09 to 4.66).

Stroke, on the other hand, was associated with previous shunt operations (OR, 4.20; 1.36 to 12.9), residual/unclosed septal defects (OR, 2.38; 1.03 to 5.51) and left-sided mechanical valves (OR, 2.67; 1.09 to 6.50). Risk factors for CAD were not associated with stroke.

In light of the present data, researchers called on physicians managing individuals with ACHD to recommend a heart-healthy lifestyle early on.

“Physicians should also be aware of the presence of risk factors such as hypertension and treat according to general guidelines,” researchers added.

Additional studies are needed to determine whether modification of the aforementioned risk factors may prevent acquired cardiovascular disease.

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Most Read Articles
3 days ago
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Pearl Toh, 2 days ago
Whether the 2017 ACC/AHA* blood pressure (BP) guidelines should be adopted in Asian countries was the topic of a much-anticipated discussion here at the Asian Pacific Society of Cardiology (APSC) Congress 2018 in Taiwan last week.