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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Risk factor modification for AMI needed in pregnant women

25 Nov 2020

Acute myocardial infarction (AMI) during pregnancy is driven by factors such as known coronary artery disease, hyperlipidaemia, obesity, and smoking history, among others, a study has found. These risk factors contribute to poor outcomes and highlight the need for modification in order to prevent AMI in the pregnant population.

The study involved a cohort of 11,297,849 women, among whom 913 women developed AMI (0.008 percent). Of these, 111 women (12.2 percent) had AMI during labour and delivery, 338 (37.0 percent) during pregnancy, and 464 (50.8 percent) during the postpartum period.

There was a clear trend of increasing AMI in pregnancy noted between 2003 and 2015 (p=0.0005). Furthermore, a lot of major adverse cardiovascular and cerebrovascular events occurred in the postpartum period (63.5 percent). Inpatient mortality was 4.5 percent.

In multivariable logistic regression models, predictors of AMI included known coronary artery disease (odds ratio [OR], 517.4, 95 percent confidence interval [CI], 420.8–636.2), heart failure (OR, 8.2, 95 percent CI, 1.9–35.2), prior valve replacement (OR, 6.4, 95 percent CI, 2.4–17.1), and atrial fibrillation (OR, 2.7, 95 percent CI, 1.5–4.7; p<0.001 for all).

With respect to known risk factors for traditional atherosclerosis, hyperlipidaemia, obesity, tobacco history, substance abuse, and thrombophilia were all associated with AMI (p<0.001).

Other significant risk factors for AMI were gestational hypertensive disorders, such as eclampsia (OR, 6.0, 95 percent CI, 3.3–10.8) and pre-eclampsia (OR, 3.2, 95 percent CI, 2.5–4.2).

Meanwhile, major adverse cardiovascular and cerebrovascular events were associated with prior percutaneous coronary intervention (OR, 6.6, 95 percent CI, 1.4–31.2) and pre‐eclampsia (OR, 2.3, 95 percent CI, 1.3–3.9).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.