Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.

Rifaximin for hepatic encephalopathy may prolong survival in patients without HCC

14 Sep 2017

Rifaximin appears to confer increased survival benefit in hepatic encephalopathy patients without hepatocellular carcinoma (HCC), in addition to reducing the risks of spontaneous bacterial peritonitis, variceal bleeding and recurrent hepatic encephalopathy, according to a study.

To evaluate whether rifaximin was associated with the risk of death and cirrhotic complications, researchers retrospectively examined data from 1,042 patients with hepatic encephalopathy who were grouped into two according to HCC status: HCC (n=621) and non-HCC cohorts (n=421).

Overall survival was the primary endpoint. Recurrence of hepatic encephalopathy and the development of spontaneous bacterial peritonitis, hepatorenal syndrome and variceal bleeding were evaluated as secondary endpoints.

In the non-HCC cohort, 145 patients received rifaximin plus lactulose (the rifaximin group) and 276 received lactulose alone (the control group). On multivariate Cox proportional hazards analysis, rifaximin had a protective effect on the risks of death (adjusted hazard ratio [aHR], 0.697; p=0.024), recurrent hepatic encephalopathy (aHR, 0.452; p<0.001), spontaneous bacterial peritonitis (aHR, 0.210; p<0.001) and variceal bleeding (aHR, 0.425; p=0.011) but not on hepatorenal syndrome (aHR, 0.598; p=0.08).

In the HCC cohort, there were 173 patients in the rifaximin group and 448 patients in the control group. Rifaximin reduced the risk of developing spontaneous bacterial peritonitis (aHR, 0.323; p<0.001); no association was observed for the risk of death (aHR, 1.177; p=0.121), variceal bleeding (aHR, 0.660; p=0.104) or recurrent hepatic encephalopathy (aHR, 0.689; p=0.057). The risk of Clostridium difficile-associated diarrhoea did not differ between the rifaximin and control groups (aHR, 0.028; p=0.338).

“Although rifaximin was not associated with lower risk of death in patients with HCC, it has been shown to be related to preventing portal hypertension-related complications. Th[e] present study may support the initiation of a large cohort study to assess the overall efficacy of rifaximin in patients with previous hepatic encephalopathy,” researchers said.

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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.