Most Read Articles
01 Aug 2014

Extracted from the speech by UNAIDS Executive Director Michel Sidibé at the opening session of the 20th International AIDS Conference (AIDS 2014) held in Melbourne, Australia.

Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.
24 Dec 2015
Imipenem-cilastatin exhibited better efficacy than piperacillin-tazobactam as empiric antibiotic for febrile neutropaenia in haematopoietic stem cell transplantation (HSCT) recipients, based on a study.

Rifabutin triple therapy safe, effective in patients with multidrug-resistant strains of H. pylori

16 Jan 2018

No standard currently exists for the growing number of patients with multidrug-resistant strains of Helicobacter pylori, but a recent study has shown the safety and reliability of a 12-day low-dose rifabutin/high-dose proton pump inhibitor (PPI) regimen in patients infected with triple-resistant strains.

Of the 756 patients enrolled in the study, 254 were infected with a triple-resistant H. pylori strains after at least one antibiotic therapy course. In total, 213 of the infected participants had benefitted from the therapy, corresponding to a cure rate of 82.9 percent (95 percent CI, 78.3‒87.5) by intention-to-treat analysis and 88.7 percent (84.7‒92.7) at per-protocol analysis.

Furthermore, multivariate analyses showed no factor that independently predicted bacterial eradication.

In a study involving the Korean population, researchers found that rifabutin-based high-dose PPI‒combined therapy as empirical rescue treatment was more effective than rifabutin-based standard-dose PPI‒combined therapy, as well as safe and well tolerated in third-line treatment. [Helicobacter 2014;19:455-461]

In this study that evaluated the efficacy of 12-day rifabutin-based triple therapy, the investigators enrolled consecutive patients with dyspeptic symptoms after at least one antibiotic therapy course for H. pylori infection harbouring triple-resistant (clarithromycin, metronidazole, levofloxacin) strains.

Participants received triple therapy with esomeprazole 40 mg bid, amoxicillin 1 g bid and rifabutin 150 mg od for 12 days. Those who failed rifabutin therapy were empirically treated based on the judgment of the treating physician.

“Eradicating Helicobacter pylori continues to be a challenge, and no treatment regimen is uniformly successful in all treated patients,” the investigators said. “Triple therapy with rifabutin and amoxicillin is a successful rescue therapy after consecutive treatment failures.”

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Most Read Articles
01 Aug 2014

Extracted from the speech by UNAIDS Executive Director Michel Sidibé at the opening session of the 20th International AIDS Conference (AIDS 2014) held in Melbourne, Australia.

Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.
24 Dec 2015
Imipenem-cilastatin exhibited better efficacy than piperacillin-tazobactam as empiric antibiotic for febrile neutropaenia in haematopoietic stem cell transplantation (HSCT) recipients, based on a study.