Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.

Rifabutin okay to use with tenofovir alafenamide in HIV patients

17 Oct 2020

Administering rifabutin with tenofovir alafenamide (TAF) does not affect the latter’s absorption in the gut, with a recent study showing that HIV patients taking both drugs stay virally suppressed.

Researchers reviewed the medical records of 22 HIV patients (median age, 37 years; 27.3 percent female) on TAF 25 mg daily. All patients were given rifabutin simultaneously for a median of 34.2 weeks to treat mycobacterial infection.

The primary outcome of viral suppression (HIV viral load <200 copies/ml [cpm]) was maintained in four out of five patients, who already had a viral load of <200 cpm at baseline, at 1 month after the start of TAF-rifabutin coadministration.

Meanwhile, of the 17 patients with viral load >200 cpm at baseline, 15 (88.2 percent) achieved viral suppression after a mean of 53 days.

Of the three patients who did not achieve or maintain viral suppression, two discontinued therapy on their own while the third patient was lost to follow-up.

The present data suggest that TAF-rifabutin coadministration is effective, despite concerns that rifabutin could reduce TAF absorption, the researchers noted.

Further studies are needed to assess pharmacokinetics and establish that TAF-containing HIV regimens can be indeed administered with rifabutin, they added.

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Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.