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Yesterday
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3 days ago
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Rheumatoid arthritis ups risk of CVD, CHF

11 Jul 2017
Mesoblast cell treatment shows promise for rheumatoid arthritis

The risks of cardiovascular disease (CVD) and congestive heart failure (CHF) are twice as higher in rheumatoid arthritis (RA) patients than in osteoarthritis (OA) patients, a new cross-sectional study in a Chinese population shows.

Comparing the medical records of 1,022 OA (mean age 58.5±0.4 years; 68.7 percent female) and RA (mean age 57.8 years; 68. Percent female) patients, matched by sex and age, a significantly higher prevalence of CVD (adjusted OR [OR], 2.19; 95 percent CI, 1.49 to 2.95; p<0.05) in the RA cohort was found.

CHF (adjusted OR, 6.95; 1.50 to 32.21; p<0.05) and atherosclerosis (adjusted OR, 4.95; 3.36 to 7.28; p<0.05) were also significantly more common in RA vs OA patients.

There was no significant difference in the prevalence of ischaemic heart disease (adjusted OR, 1.83; 0.94 to 3.56) and stroke (adjusted OR, 1.13; 0.57 to 2.25).

Before matching, the prevalence of CVD (adjusted OR, 1.86; 1.42 to 2.43; p<0.05) was also significantly greater in RA (n=1,824; mean age 52.4±0.5 years; 96.9 percent female) than in OA (n=1,995; mean age 63.0±0.3 years; 74.6 percent female) patients.

Similar trends were reported for CHF (adjusted OR, 2.09; 1.03 to 4.22; p<0.05) and atherosclerosis (adjusted OR, 2.49; 1.97 to 3.13; p<0.05).

The medical record database of Sichuan’s provincial people’s hospital was scoured for inpatients with principal diagnoses of RA or OA. Those principally diagnosed with both RA and OA were excluded.

Stroke and CVD were the primary outcomes while specific CVDs, such as IHD, atherosclerosis and CHF, were the secondary outcomes.

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Most Read Articles
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.
Pearl Toh, 14 Nov 2017
Performing percutaneous coronary intervention (PCI) on culprit lesion only, rather than a multivessel PCI, reduces the 30-day composite risk of death or severe renal failure in patients with acute myocardial infarction (MI) complicated by cardiogenic shock and multivessel disease, according to the CULPRIT-SHOCK* study presented at the TCT 2017 Congress held in Denver, Colorado, US.