Rheumatoid arthritis ups risk of CVD, CHF
The risks of cardiovascular disease (CVD) and congestive heart failure (CHF) are twice as higher in rheumatoid arthritis (RA) patients than in osteoarthritis (OA) patients, a new cross-sectional study in a Chinese population shows.
Comparing the medical records of 1,022 OA (mean age 58.5±0.4 years; 68.7 percent female) and RA (mean age 57.8 years; 68. Percent female) patients, matched by sex and age, a significantly higher prevalence of CVD (adjusted OR [OR], 2.19; 95 percent CI, 1.49 to 2.95; p<0.05) in the RA cohort was found.
CHF (adjusted OR, 6.95; 1.50 to 32.21; p<0.05) and atherosclerosis (adjusted OR, 4.95; 3.36 to 7.28; p<0.05) were also significantly more common in RA vs OA patients.
There was no significant difference in the prevalence of ischaemic heart disease (adjusted OR, 1.83; 0.94 to 3.56) and stroke (adjusted OR, 1.13; 0.57 to 2.25).
Before matching, the prevalence of CVD (adjusted OR, 1.86; 1.42 to 2.43; p<0.05) was also significantly greater in RA (n=1,824; mean age 52.4±0.5 years; 96.9 percent female) than in OA (n=1,995; mean age 63.0±0.3 years; 74.6 percent female) patients.
Similar trends were reported for CHF (adjusted OR, 2.09; 1.03 to 4.22; p<0.05) and atherosclerosis (adjusted OR, 2.49; 1.97 to 3.13; p<0.05).
The medical record database of Sichuan’s provincial people’s hospital was scoured for inpatients with principal diagnoses of RA or OA. Those principally diagnosed with both RA and OA were excluded.
Stroke and CVD were the primary outcomes while specific CVDs, such as IHD, atherosclerosis and CHF, were the secondary outcomes.